Journal of Life Science
- 제10권1호
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- Pages.45-47
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- 2000
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- 1229-1552(pISSN)
Antibacterial Activities of Nonactin from streptomyces viridochromogenes JM-4151
- Lee, Jin-Man (Department of Herb and Food Science, Kyongbuk College of Science, Chilgok-Gun, Kyongbuk, 718-850 Korea) ;
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Lee, Dong-Sun
;
- Lee, Sang-Han (Biopotency Evaluation Lab, Korea Research Institute of Bioscience and Biotechnology(KRIBB), Taejon 305-333) ;
- Hong, Soon-Duck (Department of Microbiology, College of Natural Sciences, Kyungpook National University, Taegu 702-701) ;
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Kim, Jong-Guk
(Department of Microbiology, College of Natural Sciences, Kyungpook National University, Taegu 702-701)
- 발행 : 2000.04.01
초록
Nonactin, known as an ionophore antibiotic, was antagonized by the actibity of quercetin, an oxygen radical scavenger. This compound generated superoxide radicals in Bacillus subtilis lysates. A recombination-deficient mutant strain of B. subtilis was more sensitive than a wild strain, and this hypersensitivity was reduced in the presence of dithiothreitol as an antioxidant. These results suggest that superoxide radical is important in the antibacterial action of this agent.