Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
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The Effect of Platelet Derived Growth Factor on the Myocardial Revascularization in Implantation of Rabbit Internal Mammary Artery

토끼 내유동맥의 심근이식에서 혈관재형성 촉진에 대한 혈소판 유래 성장인자의 효과

  • 김용환 (가톨릭대학교 의과대학 흉부외과학 교실) ;
  • 나석주 (가톨릭대학교 의과대학 흉부외과학 교실) ;
  • 정상훈 (가톨릭대학교 의과대학 성형외과학교실) ;
  • 문석환 (가톨릭대학교 의과대학 흉부외과학 교실) ;
  • 조건현 (가톨릭대학교 의과대학 흉부외과학 교실) ;
  • 왕영필 (가톨릭대학교 의과대학 흉부외과학 교실) ;
  • 김세화 (가톨릭대학교 의과대학 흉부외과학 교실) ;
  • 곽문섭 (가톨릭대학교 의과대학 흉부외과학 교실)
  • Published : 2000.04.01
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Abstract

Background: Coronary artery bypases grafting in the old aged is associated with high mortality and morbidity, and it is difficult to perform if the coronary artery is diffusely disease. Recently it has been known that platelet derived growth factor(PDGF), especially PDGF-BB, stimulates angiogenesis. Material and Method: New Zealand white rabbit were used. In an attempt to achieve effevtive cardiac revasculatrization without vascular anastmosis, we divided into three groups(group I : Left anterior descending artery(LAD) was occluded by ligature, group II : Bilateral internal mammary vascular pedicles were dissected and implanted into myocardium, group III : The vascular pedicles were implanted into myocardium and PDGF-BB was injected into the myocardial tissue). Two weeks after IMA implantation, the proximal region of implanted LAD was ligated. Four days after LAD ligation angiogram, triphenyl tetrazolium chloride(TTD) staining and hematoxylin eosin staining were performed. Result: 1. Survival rate in group II was significantly higher than that in group I (P<0.05), and survival rate in group III was signficantly higher than that in group II(53% vs 93%, P<0.01). 2. There were significant differences in the ratio of area of necrosis to area at risk between group I and group II, and between group II and group III (P<0.01). 3. Microangiogram for angiogenic response revealed wide area of extensive revascularization with patent vessels in group III. 4. Histologic findings of three groups showed that polymorphonuclear leukocyte infiltration was minimal in group II and none in group III. Conclusion: PDGF-BB can establish functinal cardiac revasculatization through systemic vessels implanted directly into the myocardium.

Keywords

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