Archives of Pharmacal Research
- Volume 23 Issue 1
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- Pages.72-78
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
General Pharmacological Properties of YJA20379-2, a New Antiulcer Agent
- Lee, Eun-Bang (Natural Products Research Institute, Seoul National University) ;
- Cho, Sung-Ig (Natural Products Research Institute, Seoul National University) ;
- Cheon, Seon-Ah (Natural Products Research Institute, Seoul National University) ;
- Chang, Man-Sik (Pharmacology and Toxicology Laboratory, Yung-Jin Pharmaceutical Co., Ltd.) ;
- Kim, Kyu-Bong (Pharmacology and Toxicology Laboratory, Yung-Jin Pharmaceutical Co., Ltd.) ;
- Woo, Tae-Wook (Pharmacology and Toxicology Laboratory, Yung-Jin Pharmaceutical Co., Ltd.) ;
- Chung, Young-Kuk (Pharmacology and Toxicology Laboratory, Yung-Jin Pharmaceutical Co., Ltd.)
- Published : 2000.02.01
Abstract
The general pharmacological properties of YJA20379-1 2-dimethylamino-4,5-dihydrothiazolo[4,5:3,4]pyridol[1,2-a]benzoimidazole, a novel proton pump inhibitor with antiulcer activities were investigated in mice, rats, guinea pigs and rabbits. YJA20379-2 at oral doses of 50, 100 and 200 mg/kg did not affect the general behaviour, hexobarbital hypnosis and motor coordination in mice. The drug did not have analgesic or anticonvulsant action at 200 mg/kg. Locomotor activity and body temperature were not influenced at 100 mg/kg. At a concentration up to
Keywords
- 2-Dimethylamino-4,5-dihydrothiazolo[4,5:3,4] pyridol[1,2-a] benzoimidazole;
- YJA20379-2;
- Proton pump inhibitor