Archives of Pharmacal Research
- Volume 23 Issue 1
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- Pages.42-45
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Cytotoxic Activities of 6-Arylamino-7-halo-5,8-quinolinediones against Human Tumor Cell Lines
- Ryu, Chung-Kyu (College of Pharmacy, Ewha Womans University) ;
- Kang, Hye-Yung (College of Pharmacy, Ewha Womans University) ;
- Yi, Yu-Jini (College of Pharmacy, Ewha Womans University) ;
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Lee, Chong-Ock
(Korea Research Institute of Chemical Technology)
- Published : 2000.02.01
Abstract
6-Arylamino-7-halo-5,8-quinolinediones (4a-4k, 5a-5b) were tested for in vitro cytotoxicity against human solid tumor cell lines such as A 549 (non-small cell lung). SK-OV-3 (ovarian), SK-MEL-2 (melanoma), HCT-15 (colon) and XF 498 (CNS) by SRB assay. The arylamino-7-chloro-5,8-quinolinediones 4 were also evaluated for cyclin-dependent kinase (CDK2 and CDK4) inhibitory effect. Among them, the 5,8-quinolinediones 4a and 5a with 7-(4-fluorophenyl) amino group were found to be potent cytotoxic against HCT 15, SKOV-3 and XF 498, and the compounds 4f and 4i showed inhibitory activities for the CDK4.