Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Antifungal Activity of Magnolol and Honokiol

  • Bang, Kyu-Ho (R & D Center, Kolon Pharmaceutical Inc/Department of Microbiology, Chungnam National University) ;
  • Kim, Yoon-Kwan (R & D Center, Kolon Pharmaceutical Inc) ;
  • Min, Byung-Sun (College of Pharmacy, Chungnam National University) ;
  • Na, Min-Kyun (College of Pharmacy, Chungnam National University) ;
  • Rhee, Young-Ha (Department of Microbiology, Chungnam National University) ;
  • Lee, Jong-Pill (Natural Medicinal Products Division, Korea Food & Drug Administration) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
  • Published : 2000.02.01
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Abstract

Two neolignan compound, magnolol $(5,5^{l}-diallyl-2,2^{l}-dihydroxybiphenyl, 1)$ and honokiol $(5,5^{l}-diallyl-2,4^{l}-dihydroxybiphenyl, 2)$ were isolated from the stem bark of Magnolia obovata and evaluated for antifungal activity against various human pathogenic fungi. Compound 1 and 2 showed significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of $25-100{\mu}g/ml$. Therefore, compound 1 and 2 could be used as lead compounds for the development of novel antifungal agents.

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