Archives of Pharmacal Research
- Volume 23 Issue 1
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- Pages.31-34
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis of 7,8-Dichloro-6-Nitro-1H-1,5-Benzodiazephine-2,4-(3H, 5H)-dione as a potential NMDA Receptor Glycine Site Antagonist
- Hwang, Ki-Jun (Department of Chemistry, College of Natural Science, Chonbuk National University)
- Published : 2000.02.01
Abstract
An efficient procedure for the preparation of 7,8-dichloro-6-nitro-1H-1,5-benzodiazepine-2,4-(3H, 5H)-dione(7) as a potential lead compound for the NMDA receptor glycine binding site antagonist, starting from readily available 4,5-dichloro-2-nitroaniline(8), is described. The key step in the synthesis involves the cyclization of malonic ester amide 10 to compound 11.