Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
권호 표지

Differential Modulation of ST36 Stimulation on Interleukin-6-Induced Changes of Afferent Somatosensory Transmissionto the SI Cortex of Rats

족삼리(足三里)의 전침자극(電鍼刺戟)이 흰쥐의 중추신경계(中樞神經系)에서 Interleukin-6 의 활성(活性)에 미치는 영향(影響) -구심성(求心性) 체감각(體感覺) 정보전달(情報傳達)을 중심(中心)으로-

  • Lee, Hye-Jung (Department of Meridian & Acupoint, College of Oriencal Medicine, Kyung Hee University) ;
  • Shin, Hyung-Cheul (Department of Physiology, College of Oriental Medicine, Han Lym University) ;
  • Jin, Soo-Hee (Department of Meridian & Acupoint, College of Oriencal Medicine, Kyung Hee University) ;
  • Son, Yang-Son (Department of Meridian & Acupoint, College of Oriencal Medicine, Kyung Hee University) ;
  • Yun, Dong-Hak (Department of Meridian & Acupoint, College of Oriencal Medicine, Kyung Hee University) ;
  • Lim, Sabina (Department of Meridian & Acupoint, College of Oriencal Medicine, Kyung Hee University)
  • 이혜정 (경희대학교 한의과대학 경혈학교실) ;
  • 신형철 (한림대학교 의과대학 생리학교실) ;
  • 진수희 (경희대학교 한의과대학 경혈학교실) ;
  • 손양선 (경희대학교 한의과대학 경혈학교실) ;
  • 윤동학 (경희대학교 한의과대학 경혈학교실) ;
  • 임사비나 (경희대학교 한의과대학 경혈학교실)
  • Received : 2000.10.29
  • Accepted : 2000.11.13
  • Published : 2000.12.20
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Abstract

Objectives : Acupuncture is expected to have somewhat like the efficacy parallel increasing activity of immune system in Western modem medicine. There, already, are many animal researches on activating effect of acupuncture for the immune system in peripheral organs. So, we carried out this experiment to see whether acupuncture has controlling effect on interleukin-6(IL-6) activity in rat's brain. Methods and Results : We had topical application of IL-6(1U=lpg, $10{\mu}l$) on brain of rat. It reduced afferent sensory transmission to the primary somatosensory(SI) cortex from periphery. Whereas, electrical stimulation(ES, 2Hz, 1.5V, 15min) of ST36(足三里) with application of IL-6 prominently activated afferent sensory transmission. ES of non-acupoint(proximal tail) with IL-6 showed suppression of afferent transmission. ES of ST36 without IL-6 application also exerted facilitation of afferent transmission to the SI cortex. Conclusions : Electoacupuncture(EA) on ST36 has noticeable influences on modulating activation of IL-6 in central nervous system, which do major role in immune system.

Keywords

Acknowledgement

Supported by : 보건복지부

References

  1. 침구학(상) 전국한의과대학침구.경혈학교실
  2. 대한침구학회지 v.7 침구요법이 면역기능에 미치는 영향에 관한 고찰 최민섭;고형균;김창환
  3. 대전대학교 한의학연구소 논문집 v.2 면역과 관련된 수혈 고찰 서범석;채우석
  4. 대한침구학회지 v.12 신수혈의 침자극과 황기 약침이 실험용 생쥐의 면역활성물질인 cytokine의 IL발현에 미치는 영향 김종수
  5. Jpn. J. Physiol v.47 no.2 Hisamitsu T Enhancement of splenic IFN-$\gamma$, IL-2 and NK cytotoxicity by 足三里(ST36) acupoint acrpuncture in F344 rats Yu, Y.;Kasahara, T.;Sato, T.;Guo, S.Y.;Liu, Ya.;Asano, K.
  6. Chen Tzu Yen Chiu v.20 no.1 Time course of the effect of electroacupuncture on immunomodulation of normal rat Du, L.;Jiang, J.;Cao, X.
  7. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih v.14 no.9 Effect of acupuncture on IL-2 level and NK cell immunoactivity of peripheral blood of malignant tumor patients Wu, B.;Zhou, R.X.;Zhou, M.S.
  8. 今釋황제내경소문 배병철
  9. 校勘直譯황제내경영추 홍원식
  10. 국역침구경위해석 대전 대전대한의대6기졸준위
  11. 대한한의학회지 v.10 면역질환의 한방개념과 치료에 관한 문헌적 고찰 채우석
  12. 동국대학교 한의학연구소 논문집 v.8 면역의 실험문헌적 고찰 박경미;임종국
  13. J. Clin. Neurophysiol. v.10 no.3 Effects of acupuncture on somatosensory evoked potentials: a review Xu, X.;Shibasaki, H.;Shindo, K.
  14. Neuroreport v.8 no.1 Hypothermia-induced changes of afferent sensory transmission to the SI cortex of rats and hamsters Won, C.K.;Kim, B.K.;Jung, N.P.;Oh, Y.K.;Choi, I.H.;Park, H.W.;Shin, H.C.
  15. Neuroreport v.8 no.13 Differential modulation of short and long latency sensory responses in the SI Cortex by IL-6 Shin, H.C.;Oh, S.J.;Jung, S.C.;Park, J.S.;Won, C.K.
  16. Neuroreport v.6 no.7 IL-2 suppresses afferent sensory transmission in the primary somatosensory cortex Park, H.J.;Won, C.K.;Pyun, K.H.;Shin, H.C.
  17. Basic and Clinical Immunology Peakman, M.;Vergani, D.
  18. 新 면역학 입문 中島泉
  19. Endocrinology v.127 no.4 Endotoxin-induced release of interleukin-6 from rat medial basal hypothalami Spangelo, B.L.;Judd, A.M.;Macleod, R.M.;Goodman, D.W.;Isakson, P.C.
  20. Lab. Invest. v.66 no.2 Detection of interleukin-6 and ${\alpha}_2$-macroglobulin immunoreactivity in cortex and hippocampus of alzheimer's diseae patients Strauss, S.;Bauer, J.;Ganter, U.;Jonas, U.;Berger, M.;Volk, B.
  21. Am. J. Acupuncture v.18 no.3 Immune systems, Defense mechanisms and acupuncture: Fundamental and practical aspects Bossy, J.