The Journal of Korean Physical Therapy

The Korean Society of Physical Therapy (대한물리치료학회)
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Cellular and molecular change including nerve regeneration after peripheral nerve injury

말초신경 손상 후 재생과 관련된 세포적, 분자적 변화

  • Baek Su-Jeong (Major in Physical Therapy, Graduate School of Rehabilitation Science, Taegu University) ;
  • Kim Dong-Hyun (Major in Physical Therapy, Graduate School of Rehabilitation Science, Taegu University) ;
  • Kim Jin-Sang (Department of Physical Therapy, College of Rehabilitation Science, Taegu University)
  • 백수정 (대구대학교 재활과학대학원 물리치료전공) ;
  • 김동현 (대구대학교 재활과학대학원 물리치료전공) ;
  • 김진상 (대구대학교 재활과학대학 물리치료학과)
  • Published : 2000.12.01
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Abstract

In mammals. axotomy of peripheral nerve leads to a complex. These events include swelling of cell body, disappearance of Nissl substance. Proximal and distal axon undergoes a variable deriable degree of traumatic degeneration and wallerian degeneration, respectively. Nerve injury may result in cell death or regeneration. Molecular changes include proliferation of Schwann cells, upregulation of neurotropism, neural cell adhesion molecules and cytokine. Also growth cone plays an essential role in axon guidance through interaction of cytoskeleton. We review cellular and molecular events after nerve injury and describe nerve regeneration and associated proteins.

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