Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
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Brain Metal Level in Ohjeoksan-Treated Rats

오적산(五積散)을 투여한 흰쥐의 뇌중 금속농도변화에 관한 연구

  • Min Dae-Ki (Dept. of Oriental Medicine Graduate school SangJi University) ;
  • Goh Seong-Kyu (Dept. of Oriental Medicine Graduate school SangJi University) ;
  • Lee Sun-Dong (Dept. of Preventive Oriental Medicine, SangJi University) ;
  • Wen Yong (Dept. of Health Administration, Namseoul University)
  • 민대기 (상지대학교 한의과대학 심계내과학교실) ;
  • 고성규 (상지대학교 한의과대학 심계내과학교실) ;
  • 이선동 (상지대학교 한의과대학 예방의학교실) ;
  • 문용 (남서울대학교 보건행정학과)
  • Published : 2000.12.29
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Abstract

This study was to investigate the metal accumulation from Ohjeoksan-Decoction to rat brain(Sprague Dawley). 1. In Control group, each metal concentration was within 26.65mg/kg. and in each experimental groups, was within 28.39mg/kg. And there were no significant metal concentration between control and experimental groups. Exceptionally, Cr and Ni level of control group was lower than experimental groups significantly. (p<0.05) and Cr and Ni level of experimental I group was lower than other experimental groups too. (p<0.05). But, Pb level of control group was higher than experimental groups significantly (p<0.05) Pb level of experimental I group was higher than other experimental groups(p<0.01) 2. In non-hazardous, hazardous and total metal concentration, there was no increase tendency in brain according to the high dose of OD(Ohjeoksan-Decoction) intake. Reversely, in experimental groups, hazardous metal concentration was decrease by high OD intake. (P<0.05) 3. Correlation among each metal in brain was various in each groups Briefly under the intake of Ohjeoksan-Decoction, that if very busy herb prescription , this study was defined within safety in brain metal level by P.O. during 10 days. But, there should be a more research about Pb increase by high dose OD intake

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