Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
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Effects of Tokhwalkisaengtang on LDL Oxidation in Macrophage Cell

대식세포(大食細胞) oxLDL 생성(生成)에 미치는 독활기생탕(獨活寄生湯)의 영향(影響)

  • Hwang Gwi-Seo (College of Oriental Medicine, Kyungwon University) ;
  • Song Ji-Yeon (College of Oriental Medicine, Kyungwon University)
  • 황귀서 (경원대학교 한의과대학 예방의학교실) ;
  • 송지연 (경원대학교 한의과대학 예방의학교실)
  • Published : 2000.12.29
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Abstract

The oxidative modification of low density lipoprotein(LDL) has been implicated in the development of atherosclerosis . Oxidized LDL(oxLDL) are found in macrophage foam cell , and it can induce an macrophage proliferation in atherosclerotic plaque. In this study, we investigated the hypothesis that Tokhwalkisaengtang(TK) may reduce atherosclerosis by lowering the oxidizability of LDL, To achieve this goal, we examined the effect of TK on LDL oxidation, nitric oxide production in murine macrophage cell line , and the effect of TK on cupuric sulfate-induced cytotoxicity. LDH release, and macrophage activity TK inhibited the generation of oxLDL from native LDL in macrophage cell culture, and decreased the release of LDH from cupric sulfate-stimulated macrophage. In other experiments, TK activated macrophase cell, and increased the survival rate, and enhanced nitric oxide production in macrophage.

Keywords

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