Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Inhibitory Effect of Apoptosis of Human Astrocytes by Juniper Oil

신경교(神經膠) 성상세포(星狀細胞)에서 쥬니퍼오일에 의한 세포자멸사(細胞自滅死)의 억제(抑制) 효과(效果)

  • Kim Tae-Heong (Dept. of Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • Kim Tae-Heon (Dept. of Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • Lee Sung-Ryull (Dept. of Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • Lyu Yeoung-Su (Dept. of Neuropsychiatry, College of Oriental Medicine, Won Kwang University)
  • 김태형 (원광대학교 한의과대학 신경정신과학교실) ;
  • 김태헌 (원광대학교 한의과대학 신경정신과학교실) ;
  • 이성률 (원광대학교 한의과대학 신경정신과학교실) ;
  • 류영수 (원광대학교 한의과대학 신경정신과학교실)
  • Published : 2000.12.01
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Abstract

In previous studies, heat shock has been reported to induce the apoptosis or programmed cell death through the activation of caspase-3. 1 investigated the effect of juniper pure essential oil on the heat shock-induced apoptosis in human astrocyte cell line CCF-STTGI. Treatment of the astrocytes with heat shock markedly induced apoptotic cell death. However, pretreatment of the astrocytes with juniper oil ingibited the heat shock-induced apoptosis. To determine whether juniper inhibits the heat shock-induced activation of these apoptotic proteases, activation of CPP32 was assessed by Western blotting. Consistent with flow cytometry. DNA fragmentation and giemsa staining, heat shock-induced activation of CPP32 was blocked by juniper oil. Poly(ADP-ribose) polymerase (PARP), cysteine protease substrates were fragmented as a consequence of apoptosis by heat shock. Juniper oil inhibited the PARP fragmentation. This juniper oil also inhibited the heat shock-induced activation of caspase-3. These results suggest that juniper oil may modulate the apoptosis through the activation of the interleukin-1-converting enzyme-like protease.

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