The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Gami-oryungsan on Antioxidation in Rat's Liver

Bromobenzene으로 유발된 흰쥐의 간손상(肝損傷)에서 가미오령산이 항산화(抗酸化) 작용(作用)에 미치는 영향

  • 김형환 (동국대학교 한의과대학 내과학교실) ;
  • 김미랑 (동국대학교 한의과대학 내과학교실) ;
  • 박철수 (동국대학교 한의과대학 내과학교실) ;
  • 김종대 (동국대학교 한의과대학 내과학교실)
  • Published : 2000.11.30
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Abstract

Objective : This is the experimental paper to investigate the effects of Gami-oryungsan(GO) on decreasing the activities of free radicals. Methods : We used three different group; In the normal group, we injected Gami-oryungsan extract intraperitoneally daily for 15days(90mg/kg), bromobenzene(310mg/kg) for 2days and injected normal saline in the control group. Results : We have observed the effects of Gami-oryungsan about the damage of rat's liver induced by bromobenzene. We can find the level of lipid peroxidation and type conversion ratio of xanthine oxidase decreased compared to the case of bromobenzene-treated group. The enzyme of activities of superoxide dismutase, catalase and glutathione peroxidase highly increased in Gami-oryungsan pre-acupunctured group compared to the group treated with only bromobenzene. The level of glutathione in Gami-oryungsan pre-acupunctured group was increased as highly as normal group. Also it was not seen special effects concerning aldehyde oxidase. Conclusions : Gami-oryungsan extract recovers the damage of liver due to bromobenzene intoxication by decreasing the lipid peroxidation.

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