대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

방풍당귀음(防風當歸飮)이 중대뇌동맥 폐쇄 후 재관류 모델에 미치는 영향 -육안.광학현미경 소견-

The effect of Bangpungdangkwi-eum extracts on reperfusion following the middle cerebral artery occlusion in rats

  • 홍천표 (동국대학교 한의과대학 내과학교실) ;
  • 박인식 (동국대학교 한의과대학 해부학교실) ;
  • 신길조 (동국대학교 한의과대학 내과학교실) ;
  • 이원철 (동국대학교 한의과대학 내과학교실) ;
  • 정승현 (동국대학교 한의과대학 내과학교실)
  • Hong, Cheon-Pyo (Department of Internal Medicine, Dongguk University, College of Oriental Medicine) ;
  • Park, In-Sick (Department of Anatomy, Dongguk University, College of Oriental Medicine) ;
  • Shin, Gil-Cho (Department of Internal Medicine, Dongguk University, College of Oriental Medicine) ;
  • Lee, Won-Chul (Department of Internal Medicine, Dongguk University, College of Oriental Medicine) ;
  • Jeong, Sung-Hyun (Department of Internal Medicine, Dongguk University, College of Oriental Medicine)
  • 발행 : 2000.10.30
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초록

To evaluate the effect of Bangpungdangkwi-eum extracts on reperfusion following the middle cerebral artery occulsion in Sprague Dawley rats, the neuron protection effect were investigated through examining the size of cerebral infarction, cerebral edema, and the morphologic change of neuron. The results were obtained as follows; 1. The size of cerabral infarction in sample group is significantly decreased compared with that in control group. Sample group has approximately 17% cerebral infarction parts induced by ischemia in cerebrum while control group has approximately 22%. 2. The volume of cerebral edema in sample group is significantly decreased compared with that in control group. The volumn in sample group is increased by approximately 4.4% compared with that in normal group while that in control group is increased by approximately 7.7%. 3. The optical microscopic examination reveals that the damage of neurons in the ischemic parts and CA1 and CA3 region of hippocampus in the same side of the ischemic parts was the most high and the damage in sample group is decreased compared with that in control group.

키워드

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