The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
권호 표지

Experimental Study on the Immunoregulative Action of Kamiboatang

가미보아탕(加味補兒湯)의 면역조절작용(免疫調節作用)에 대(對)한 실험적(實驗的) 연구(硏究)

  • Jeong Yeon-Hee (Dept. of Pediatrics, College of Oriental Medicine, Dae Jeon University) ;
  • Yoo Dong-Yeol (Dept. of Pediatrics, College of Oriental Medicine, Dae Jeon University)
  • 정연희 (대전대학교 대학원 한의학과 소아과) ;
  • 유동열 (대전대학교 한의과대학)
  • Published : 2000.12.30
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Abstract

The purpose of this study was to investigate the effects of Kami boatang(KBT) on the immune cells in Balb/c mice. KBT (500mg/kg) was administerd p.o. once a day for 7 days. KBT enhanced the proliferation of thymocytes and splenocytes. KBT enhanced the subpopulation of helper T(Th) cells, but did not affect the subpopulation of Thyl/B220 cells and Th/Tc cells in splenocytes. KBT enhanced the production of ${\gamma}$-interferon and interleukin-2 in thymocytes, but decreased the production of interleukin-4. KBT enhanced the production of ${\gamma}$-interferon, interleukin-2 and interleukin-4 in splenocytes and serum. KBT suppressed the production of nitric oxide, and enhanced the phagocytic activity in peritoneal macrophages. These results suggest that KBT has a potent activity on the immune response via the increase of the production of cytokines and phagocytic activity in vivo.

Keywords

References

  1. 韓方病院 處方集 大田大學校 韓方病院
  2. 方藥合編 黃度淵
  3. 方藥指針講義抄錄 孟華燮
  4. 韓方臨床四十年 朴炳昆
  5. 東醫方劑學 尹吉榮
  6. 方藥合編解設 申載鏞
  7. 醫學正傳 虞搏
  8. 東醫小兒科學 丁奎萬
  9. 小兒難病回春新方 蔡化理
  10. 病原微生物學 李鐘訓
  11. 內科學 李文鎬
  12. 精校黃帝內徑 洪元植(編)
  13. 免疫에 관한 東洋醫學的 考察 趙鐘寬
  14. 大韓韓醫學會誌 v.6 no.2 歸茸湯이 免疫反應에 미치는 實驗的 硏究 金德鎬
  15. 東醫病理學會誌 四君子湯, 四物湯 및 八物湯이 Prednisolone으로 誘發된 생쥐의 免疫反應低下에 미치는 影響 金聖勳
  16. 大韓韓方小兒科學會誌 v.8 no.1 錢氏白朮散이 생쥐의 體液性免疫反應과 細胞性免疫反應에 미치는 效果 沈文敬
  17. 圓光大學校大學院 博士學位論文 蔘茶白朮散 煎湯液投與가 Mouse의 生體 및 試驗管內 免疫反應에 미치는 效果 李漢哲
  18. 大韓韓方小兒科學會誌 v.7 no.5 補兒湯이 免疫反應에 미치는 實驗的 硏究 元鐘勳
  19. 大田大學校韓醫科大學院 博士學位論文 加減補兒湯의 造血 및 免疫增進에 관한 硏究 金允姬
  20. Proc. Natl. Acad. Sci. USA v.75 Planning for lymphocytes: A method for cell selection Wysocki, L.J.;Sato, V.L.
  21. J. Immunol. v.120 Characterization of lymphocyte-activating factor(LAF) produced by the macrophage cell line P388D1 Mizel. S.B.; Openheim, J.J.;Rosensteich, D.L.
  22. J. Immunol. Methods. v.65 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays Mosmann, T.
  23. J. Immunol. Methods. v.129 A simple and rapid method to determine hematopoietic growth factor activity Kotnic, V.;Fleischmann, W.R.Jr
  24. J. Exp. Med. v.179 Purification and characterization of the Fas-ligand that induces apoptosis Suda, T.;Nagata, S.
  25. Infec. Immunity. v.59 no.9 Killing of Plasmodium faciparum in vitro by nitric oxide derivatives Rockett, K.A.;Awburn, M.M.;Cowden, W.B.;Clark, I.A.
  26. J. Immunol. Methods. v.174 Chemiluminenscence and nitrite determinations by the MALU macrophage cell line Boudard, F.;Vallot, N.;Cabaner, C.;Bastide, M.
  27. J. Immunol. Methods. v.112 Measurement of phagocyte chemiluminenscence in a microtiter plate format Blair, A.L.;Cree, I.A.;Beck, J.S.;Hating,M.J.G.
  28. J. Immunol. C. v.162 A rapid and simple microfluorometric phagocytosis assay Chok, P.W.;Choon, S.P.;Benjamin, H.S.
  29. J. Immunol. v.147 no.1 Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation Albina, J.E.;Abate, J.A.;Henry, W.L.
  30. Infect. Immunol. v.45 Intra- and extracellular evevts in luminol-dependent chemiluminescence of polymorphonuclear leukocytes Breiheim, G.;Stendahl, O.;Dahlgren, C.
  31. 方藥合編解設 申載鏞
  32. 小兒藥證直訣 v.上;下 錢乙
  33. 醫方集 解 汪認庵
  34. 大韓韓方小兒科學會誌 v.4 六味地黃丸의 小兒疾患 治療에 대한 文獻的 考察 李進容
  35. 大韓韓方小兒科學會誌 v.4 no.1 小兒虛證에 관한 文獻的 考察 愼元揆
  36. 金匱要略 張仲景
  37. 中國醫學史 洪元植
  38. 幼幼集成 陳復正
  39. 證治準귀繩 王肯堂
  40. 東醫寶鑑 許浚
  41. 太平惠民和劑局方 陳師文
  42. 萬病醫藥顧問 v.上 陸靑節
  43. 本草學 全國韓醫科大學本草學敎授(編)
  44. 新編中藥大辭典 新文豊出版公司
  45. 本草綱目 李時珍
  46. 湯液本草 王好古
  47. 圖說漢方醫藥大辭典 陳存仁
  48. 韓方小兒科學 臨床實習 敎材 丁奎萬 (外2人)
  49. 石室秘錄 陳士鐸
  50. 醫學入門 李挺
  51. 慶熙大學校 碩士學位論文 白朮과 拘杞子가 생쥐의 細胞性 및 體液性 免疫反應에 미치는 影響 羅瑛杰
  52. 中醫免疫學 載新民
  53. 上海中醫學雜誌 v.六 健脾中藥防治消化道惡性腫瘤的 作用原理硏究 邱佳信 (외5人)
  54. 全州又石大學大學院 博士學位論文 甘草의 免疫調節作用에 關한 硏究 韓宗鉉
  55. 中醫病理硏究 匡調元
  56. 中醫雜誌 v.25 no.11 中醫免疫思想及成就 傳芳
  57. 中醫學基礎 上海中醫學院
  58. 臟腑辨證論治 金完熙;崔達永
  59. 東醫病理學 文濬典
  60. 實用中醫內科學 方藥中(외)
  61. 東洋醫學槪論 姜孝信
  62. 靈樞經校釋(下冊) 河北醫學院(釋)
  63. 大韓韓醫學會誌 v.11 no.2 免疫疾患의 韓方槪念과 治療에 關한 文獻的 考察 蔡禹錫
  64. 中醫基礎理論 梅光慧
  65. 大韓韓醫學會誌 v.11 no.2 免疫과 알레르기 具本泓
  66. 新編實用鍼灸學 李文憲(編)
  67. 免疫學入門 金周德;金聖光(譯)
  68. Integrins and other cell 1.adhesion FASEB J. v.4 Alberda, S.M.;Buck, C.A.
  69. Adv. Immunonol. v.4 Effect ofbacteia and bacterial products on antibody response Munoz, J.
  70. Annu. ev. Microbial. v.30 The adjuvant effect of microbial products on the immune response White, R.G.
  71. 대한의학협회지 v.21 no.7 체액 면역 기전에 의한 숙주방어 양용태
  72. 小兒科學 洪彰義
  73. Advances in Immunology v.53 The role of CD4 and CD8 in T cell activation and differentiation Miceli, M.C.;Parnes, J.R.
  74. Saunders Company(2nd) Cellular and molecular immunology Abbas, A.K.;Lichtman, A.H.;Pober, J.S.
  75. J. Natl. Cancer Instit. v.84 no.11 Overproduction of nitric oxide in cytokine-mediated and septic shock Kilbourn, R.G.;Griffith, O.W.
  76. Immunolgy Letters. v.52 Nitric oxide induces apoptosis in mouse splenic T lymphocytes Okkuda, Y.;Sakada, S.;Shimaoka, M.;Yanagihara, T.
  77. J. Leucocyte Biol. v.41 Zymosan-stimulated production of phosphatidic acid by macrophages: relationship to release of superoxide anion and inhibnition by agents that increase intracellular cyclic AMP Channon, J.Y.;Leslie, C.C.;Johnston, Jr. R.B.
  78. Kor. J. Immunol. v.18 Nitric oxide inhibita macrophage pseudopodia formation in the activated macrophages Jun, C.D.;Park, S.K.;Kim, J.M.;Kim, J.D.;Kim, S.H.