대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)

  • 제14권2호
  • /
  • Pages.47-60
  • /
  • 2000
  • /
  • 1226-8038(pISSN)
  • /
  • 2287-9463(eISSN)
대한한방소아과학회 (The Association of Korean Oriental Pediatrics)
권호 표지

가미귀용탕(加味歸茸湯)이 생쥐의 면역세포(免疫細胞)에 미치는 영향(影響)

Effect of Kami-Kwiryong-Tang on immune cells in BALB/c Mice

  • 한재경 (대전대학교 한의과대학 소아과) ;
  • 김윤희 (대전대학교 부속 한방병원 소아과) ;
  • 유동열 (대전대학교 한의과대학)
  • Han Jae-Kyung (Dept. of Pediatrics, College of Oriental Medicine, Taejon University) ;
  • Kim Yun-Hee (Dept. of Pediatrics, College of Oriental Medicine, Taejon University) ;
  • Yoo Dong-Yeol (Dept. of Pediatrics, College of Oriental Medicine, Taejon University)
  • 발행 : 2000.12.30
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초록

The purpose of this research was to investigate the effects of Kami Kwiryong Tang (KKT) on the immune cells in BALB/c mice. KKT (500mg/kg) was administerd p.o. once a day for 7 days. KKT decreased the proliferation of thymocytes, but did not affect the proliferation of splenocytes. KKT enhanced the subpopulation of Th (CD4+CD8- single positive cells) cells in splenic T-lymphocytes, but decreased the subpopulation of Th cells in thymocytes. KKT enhanced the production of ${\gamma}$-interferon and interleukin-2, but did not affect the production of interleukin-4 in mice serum. KKT did not affect the production of nitric oxide, but enhanced the phagocytic activity in peritoneal macrophages. These results suggest that KKT is a potent prescription on immune response via the production of cytokines from splenic Th1 cells and the increase of phagocytic activity in vivo.

키워드

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