Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Effects of the Aqueous Extract of Epimedii Herba on the Production of Antibodies in Mice

음양곽(淫羊藿) 수추출물(水抽出物)이 생쥐의 항체생성(抗體生成)에 미치는 영향(影響)

  • Kim Joung-Hoon (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Park Joung-Suk (Dept. of Pharmacy, Graduate School of Wonkwang University) ;
  • Lee Kwan-Sun (Dept. of Oriental Medicine, Graduate School of Wonkwang University) ;
  • Lim Kyu-Sang (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Kwang-Gyu (Dept. of Pathology in Wooseok University) ;
  • Woo Won-Hong (Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 김정훈 (원광대학교 한의학전문대학원) ;
  • 박정숙 (원광대학교 대학원 약학과) ;
  • 이관순 (원광대학교 대학원 한의학과) ;
  • 임규상 (원광대학교 한의학전문대학원) ;
  • 이광규 (우석대학교 한의과대학 병리학교실) ;
  • 우원홍 (원광대학교 한의학전문대학원)
  • Published : 2000.12.05
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Abstract

Epimedii Herba is an important traditional herb medicine widely used as a tonic. However, the mechanism of action of this drug on the immune system is not well studied. This study was performed to elucidate the effects of the aqueous extract of Epimedii Herba on the production of antibodies in mice. Antibodies in serum were detected in male ICR mice treated with the aqueous extract of Eplmedii Herba (AEEH) at a dosage of 40, 120, and 360mg/kg orally for 2 weeks. Effects of oral administration of AEEH on antibody forming responses were measured by enzyme linked immunosorbent assay (ELISA) of immunoglobulin (Ig) levels in serum. The results were as follows; 1. Epimedii Herba slightly decreased body weight gain. 2. Epimedii Herba significantly increased the relative spleen weight. 3. Epimedii Herba significantly increased total serum IgG levels. 4. Epimedii Herba significantly enhanced total serum IgG1 levels. 5. Epimedii Herba significantly increased total serum IgG2a levels. 6. Epimedii Herba markedly increased total serum IgM levels. These findings demonstrate that Epimedii Herba significantly enhances the production of antibodies at therapeutic concentrations, and suggest that administration of Epimedii Herba may prevent the host from immunologic diseases.

Keywords

References

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