Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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The Histopathologic Effects of Jungcheonwhadamgangki-tang on the Experimental Asthma induced by Ovalbumin

정천화담항기탕(定喘化痰降氣湯)이 ovalbumin으로 유발된 천식(喘息)에 미치는 영향(影響)

  • An Tae-Ho (Department of Internal Medicine, Daegu Oriental Hospital of Kyungsan University) ;
  • Hwang Hui-Jeung (Department of Internal Medicine, Daegu Oriental Hospital of Kyungsan University) ;
  • Kim Dae-Jun (Department of Internal Medicine, Daegu Oriental Hospital of Kyungsan University) ;
  • Park Ji-Hyeon (Department of Internal Medicine, Daegu Oriental Hospital of Kyungsan University) ;
  • Choi Hae-Yun (Department of Internal Medicine, Daegu Oriental Hospital of Kyungsan University) ;
  • Kim Jong-Dae (Department of Internal Medicine, Daegu Oriental Hospital of Kyungsan University)
  • 안태호 (경산대학교 부속 대구한방병원 내과학교실) ;
  • 황희정 (경산대학교 부속 대구한방병원 내과학교실) ;
  • 김대준 (경산대학교 부속 대구한방병원 내과학교실) ;
  • 박지현 (경산대학교 부속 대구한방병원 내과학교실) ;
  • 최해윤 (경산대학교 부속 대구한방병원 내과학교실) ;
  • 김종대 (경산대학교 부속 대구한방병원 내과학교실)
  • Published : 2000.12.05
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Abstract

Objectives: In order to evaluate the effect of jungcheonwhadamgangki-tang on Balb/c mouse of allergy-sensitive to bronchial asthma induced by ovalbumin. Methods: The changes of diameter lumen of trachea which was upper respiratory organ, weight and gross appearance of lung, histology of lung and trachea, numbers of inflammatory cells in the bronchoalveolar lavage fluld(BALF) were observed. Results : The results are obtained as follows. 1. The diameters of trachea lumen were significantly increased in Jungcheonwhadam gangki-tang treated group as compared with control group. 2. Inflammatory cells including neutrophil and eosinophil in BALF were significantly. in Jungcheonwhadamgangki-tang treated group as compared with control group. 3. Weight of lung and black spots, which resulted from infiltration of inflammatory were significantly decreased in Jungcheonwhadamgangki-tang treated group as compared with control group.4. Hypertrophy of mucous membrane of trachea and bronchus and bronchioles in the lung, peritracheal, peribronchus and peribronchiolar inflammatory cell infiltration, and mucoid exudate deposit in the lumen were significantly decreased in Jungcheonwhadamgangki-tang treated group as compared with control group. Conclusions : It is considered that Jungcheonwhadamgangki-tang has somewhat favorable effect on the bronchial asthma because the bronchial asthma specific series of abnormalities in respiratory system were decreased after oral administration of Jungcheonwhadamgangki-tang in this study. In future, it is needed that the toxicological and dosage specific study of Jungcheonwhadamgangki-tang to use against bronchial asthma with safe.

Keywords

References

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