Journal of the Korean Association of Oral and Maxillofacial Surgeons
- 제26권3호
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- Pages.245-253
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- 2000
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- 2234-7550(pISSN)
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- 2234-5930(eISSN)
Comparative genomic hybridization 기법을 이용한 인체 구강암의 유전자 변화에 대한 연구
GENETIC ALTERATIONS OF HUMAN ORAL CANCERS USING COMPARATIVE GENOMIC HYBRIDIZATION
- 이명렬 (한양대학교 의과대학 치과학교실) ;
- 심광섭 (한양대학교 의과대학 치과학교실) ;
- 이영수 (한양대학교 의과대학 치과학교실) ;
- 우순섭 (한양대학교 의과대학 치과학교실) ;
- 공구 (한양대학교 의과대학 병리학교실)
- Lee, Myeong-Reoyl (Dept. of Dentistry, College of Medicine, Hanyang University) ;
- Shim, Kwang-Sup (Dept. of Dentistry, College of Medicine, Hanyang University) ;
- Lee, Young-Soo (Dept. of Dentistry, College of Medicine, Hanyang University) ;
- Woo, Soon-Seop (Dept. of Dentistry, College of Medicine, Hanyang University) ;
- Kong, Gu (Dept of Pathology, College of Medicine, Hanyang University)
- 발행 : 2000.06.30
초록
The development and progression of oral cancer is associated with an accumulation of multiple genetic alterations through the multistep processes. Comparative genomic hybridization(CGH), newly developed cytogenetic and molecular biologic technique, has been widely accepted as a useful method to allow the detection of genetic imbalance in solid tumors and the screening for chromosome sites frequently affected by gains or losses in DNA copy number. The authors examined 19 primary oral squamous cell carcinomas using CGH to identify altered chromosome regions that might contain novel oncogenes and tumor suppressor genes. Interrelationship between these genetic aberrations detected and major oncogenes and tumor suppressor genes previously recognized in carcinogenesis of oral cancers was studied. 1. Changes in DNA copy number were detected in 14 of 19 oral cancers (78.9%, mean: 5.58, range:
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