Advances in Traditional Medicine
- Volume 1 Issue 1
- /
- Pages.82-88
- /
- 2000
- /
- 2662-4052(pISSN)
- /
- 2662-4060(eISSN)
Cichorium Intybus inhibits mast cell-mediated immediate-type allergic reactions
- Jippo, Tomoko (Department of Pathology, Osaka University Medical School) ;
- Nomura, Shintaro (Department of Pathology, Osaka University Medical School) ;
- Kitamura, Yukihiko (Department of Pathology, Osaka University Medical School)
- Published : 2000.02.29
Abstract
We investigated the effect of aqueous extract of Cichorium intybus (CIAE) on mast cell-mediated immediate type allergic reactions. CIAE dose-dependently inhibited systemic anaphylactic reaction induced by compound 48/80 in mice. Especially, CIAE inhibited compound 48/80-induced anaphylactic reaction 100% with the dose of 1000 mg/kg. CIAE 1000 mg/kg also significantly inhibited local anaphylactic reaction activated by anti-dinitrophenyl (DNP) IgE. When mice were pretreated with CIAE at a concentration ranging from 0.1 to 1000 mg/kg, the plasma histamine levels were reduced in a dose-dependent manner. CIAE (1 to 1000 g/ml) dose-dependently inhibited histamine release from the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. These results indicate that CIAE inhibits mast cell-mediated immediate-type allergic reactions.
Keywords