Journal of Pharmaceutical Investigation

  • 제30권1호
  • /
  • Pages.47-50
  • /
  • 2000
  • /
  • 2093-5552(pISSN)
  • /
  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
권호 표지

유산균을 안정화시킨 마이크로캅셀의 제조 및 평가

Microcapsules for Stabilization of Lactic Acid Bacteria

  • 전홍렬 (일양약품(주) 중앙연구소) ;
  • 박동우 (일양약품(주) 중앙연구소) ;
  • 이영재 (일양약품(주) 중앙연구소) ;
  • 권석형 (중앙대학교 약학대학) ;
  • 최영욱 (중앙대학교 약학대학)
  • 발행 : 2000.03.20
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초록

A new technique has been developed for the preparation of Lactobacillus microcapsules to enhance the stability against high temperature, humidity, gastric acid and bile acid. Employing fluidized bed coating, primary sub-coating was processed in non-organic solvent system, so that Lactobacillus did not directly contact with organic solvent. Secondary enteric-coating was processed in organic solvent with low temperature $(below\;33^{\circ}C)$ technique, which minimized the heat labilability of Lactobacillus. Survival rate of Lactobacillus within microcapsule was not less than 95% and acid tolerance was above 30% in the artificial gastric acid. Further more it was dissolved in the artificial intestine juice within 2-3 hr. Average size of Lactobacillus microcapsules was $450\;{\mu}m$(25-50 mesh) and its viability was above 90% in the direct tableting.

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