Journal of Pharmaceutical Investigation
- 제30권1호
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- Pages.33-37
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- 2000
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
히드록시프로필-베타-시클로덱스트린과 피록시캄 및 테녹시캄 간의 복합체 형성
Complexation of Piroxicam and Tenoxicam with $Hydroxypropyl-{\beta}-cyclodextrin$
- Kim, Ju-Hyun (College of Pharmacy, Chosun University) ;
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Choi, Hoo-Kyun
(College of Pharmacy, Chosun University)
- 발행 : 2000.03.20
초록
One of the methods to increase the solubility of a drug is to use complexation with a cyclodextrin. Due to the hydrophobic nature of the interior cavity of the cyclodextrin, it has been known that undissociated lipophilic drugs can be included within the cyclodextrin by hydrophobic interaction. Recently, inclusion of hydrophilic or dissociated form of a drug has been investigated. In this study, the synergism of pH and complexation with
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