스트렙토키나제를 함유하는 스텔스$^{\circledR}$ 리포좀의 제조 및 평가

The Preparation and Evaluation of Streptokinase-entrapped $Stealth^{\circledR}$ Liposome

$Stealth^{\circledR}$ liposomes entrapped with streptokinase were prepared to improve the physical stability of conventional liposomes. The particle size distribution, dissolution rate and entrapping efficiency of the $Stealth^{\circledR}$ liposomes were studied. The entrapping efficiency of streptokinase into conventional liposomes was proportional to the total lipid and cholesterol amounts. In $Stealth^{\circledR}$ liposomes, the entrapping efficiency of streptokinase was increased with the increase of DPPE-PEG(5,000) amount. The particle size of $Stealth^{\circledR}$ liposomes decreased with the increase of DPPE-PEG(5,000) amount. The dissolution rate of streptokinase from conventional liposomes was decreased by addition of cholesterol. The dissolution rate of streptokinase from the $Stealth^{\circledR}$ liposomes was also decreased by addition of DPPE-PEG(5,000).