한국식품과학회지 (Korean Journal of Food Science and Technology)
- 제32권6호
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- Pages.1371-1378
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- 2000
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- 0367-6293(pISSN)
아가리쿠스버섯(Agaricus blazei Murill) 추출물의 항돌연변이원성 및 세포독성 효과
Antimutagenic and Cytotoxicity Effects of Agaricus blazei Murill Extracts
- 지정환 (강원대학교 식품생명공학부) ;
- 김미남 (강원대학교 식품생명공학부) ;
- 최근표 (강원대학교 식품생명공학부) ;
-
정차권
(한림대학교 생명과학부) ;
- 함승시 (강원대학교 식품생명공학부)
- Ji, Jeong-Hwan (Division of Food and Biotechnology, Kangwon National University) ;
- Kim, Mi-Nam (Division of Food and Biotechnology, Kangwon National University) ;
- Choi, Kun-Pyo (Division of Food and Biotechnology, Kangwon National University) ;
-
Chung, Cha-Kwon
(School of Lifescience, Hallym University) ;
- Ham, Seung-Shi (Division of Food and Biotechnology, Kangwon National University)
- 발행 : 2000.12.30
초록
S. typhimurium TA98과 TA100을 이용한 Ames test에서는 아가리쿠스버섯 메탄올 추출물 모두 시료자체의 돌연변이원성은 없는 것으로 나타났다. 아가리쿠스버섯 메탄올 추출물
This study was performed to determine the antimutagenic and cytotoxic effect of Agaricus blazei Murill methanol extract on Salmonella typhimurium TA98, TA100 and human cancer cell lines using Ames test and cytotoxicity assay, respectively. In Ames test, methanol extract from A. blazei Murill did not exhibit any mutagenicity and most of the samples showed high antimutagenic effects against mutation induced by N-methyl-N'-nitro-N-nitrosoguanidine(MNNG), 4-nitroquinoline-1-oxide(4NQO), 3-amino-1,4-dimethyl-5H-pyrido [4,3-b] indol(Trp-P-1) and