생약학회지 (Korean Journal of Pharmacognosy)
- 제31권4호
- /
- Pages.373-382
- /
- 2000
- /
- 0253-3073(pISSN)
- /
- 2288-9299(eISSN)
가미혈부축어탕 Hexane층의 항혈전활성과 뇌손상 보호효과
Antithrombotic Activity and Protective Effects of hexane fraction of Kamihyulbuchukeotang (KHBCT) on brain injury by KCN and MCA occlusion
- 이민섭 (대전대학교 한의과대학) ;
- 노석선 (대전대학교 한의과대학) ;
- 임낙철 (대전대학교 한의과대학) ;
- 송호철 (경희대학교 동서의학대학원) ;
-
신순식
(동의대학교 한의과대학)
;
- 김성훈 (경희대학교 동서의학대학원)
- Lee, Min-Seop (Department of Oriental Medicine, Taejon University) ;
- Roh, Seok-Sun (Department of Oriental Medicine, Taejon University) ;
- Lim, Rak-Cheol (Department of Oriental Medicine, Taejon University) ;
- Song, Ho-Chul (Department of Oncology, Kyunghee University) ;
-
Shin, Soon-Shik
(Department of Oriental Medicine, Dong-Eui University)
;
- Kim, Sung-Hoon (Department of Oncology, Kyunghee University)
- 발행 : 2000.12.30
초록
This study was performed to investigate the antithrombotic activity and protective effect of hexane fraction of Kamihyulbuchukeotang (KHCTH) on brain injury by KCN and MCA occlusion a prescription of HCT added with Lumbricus and Notoginseng Radix. Experiemental parameters are brain ischemia by MCA occlusion assay, KCN-induced brain injury, pulmonary thrombosis and platelet aggregation assay. The results were summarized as follows; 1. KHCTH extracts significantly inhibited the duration of KCN-induced coma (67%) and mortality (80%). 2. KHCTH extracts significantly suppressed brain ischemic area and edema following MCA occlusion and protected neuron cells as compared with control data. 3. KHCTH extracts inhibited pulmonary thrombosis induced by collagen and epinephrine. 4. KHCTH extracts inhibited platelet aggregation induced by collagen, ADP as agonist up to 76.9% and 32.3% respectivey at 1 mg/ml more effective than water extract of KHCT These data suggested that KHCTH could be applied as the protector of brain ischemia and injury and antithrombotic agent.