Korean Journal of Pharmacognosy (생약학회지)
- Volume 31 Issue 1
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- Pages.77-81
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- 2000
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Cytotoxic Constituents from Notopterygium incisum
- Nam, Nguyen-Hai (College of Pharmacy, Chungnam National University) ;
- Huong, Ha Thi Thanh (College of Pharmacy, Chungnam National University) ;
- Kim, Hwan-Mook (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
- Ahn, Byung-Zun (College of Pharmacy, Chungnam National University)
- Published : 2000.03.30
Abstract
The MeOH extract of Notopterygium incisum showed a strong cytotoxicity against B16 murine melanoma cell line. From this extract three furanocoumarins including bergamottin, isoimperatorin, notopterol and one polyacetylenic compound (falcarindiol) together with one phenylpropanoid (caffeic acid methyl ester) and one triterpenoid (pregnenolone) were isolated. The isolated compounds were evaluated for cytotoxic activity against four kinds of cancer cell lines, e.g. P388 (murine lymphocytic leukemia), B16 (murine melanoma), A549 (human lung carcinoma) and SK-OV-3 (human ovarian cancer). Among the isolates, falcarindiol and caffeic acid methyl ester expressed a significant antiproliferative activity against all tested cell lines.