Natural Product Sciences
- 제6권4호
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- Pages.170-178
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- 2000
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- 1226-3907(pISSN)
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- 2288-9027(eISSN)
Effects of Naturally Occurring Flavonoids on Inflammatory Responses and Their Action Mechanisms
- Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University) ;
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Son, Kun-Ho
(Department of Food and Nutrition, Andong National University) ;
- Chang, Hyeun-Wook (College of Pharmacy, Yeungnam University) ;
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Kang, Sam-Sik
(Natural Products Research Institute, Seoul National University)
- 발행 : 2000.12.01
초록
Flavonoids are natural polyphenolic compounds widely distributed in plant kingdom. Although many flavonoids were found to show anti-inflammatory activity in vitro and in vivo, the potency of anti-inflammatory activity was not enough for a clinical trial. Thus, a search for finding potential flavonoid molecules is continuing. In this review, in vivo anti-inflammatory activity of various flavonoid derivatives is summarized mainly based on the results obtained in authors' laboratories. Among them, several biflavonoids such as amentoflavone and ginkgetin were found to possess anti-inflammatory activity on animal models of acute/chronic inflammation comparable to nonsteroidal and steroidal anti-inflammatory drugs currently used. In respect of their action mechanisms, the effects on arachidonic acid metabolism and nitric oxide production were described. Some flavonoids directly inhibit cyclooxygenase and/or lipoxygenase. Biflavones such as ochnaflavone and ginkgetin are inhibitors of phospholipase
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