Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antimutagenic and Antileukemic Activities Aloe vera L.

  • Lee, Keyong-Ho (Laboratory of Experimental Pathology, Korea Cancer Center Hospital) ;
  • Kang, Hee-Gon (Seoul Public Health and Environment Research Institute) ;
  • Cho, Choa-Hyoung (Department of Food Engineering, Iksan National College) ;
  • Lee, Moon-Joon (Department of Food Engineering, Iksan National College) ;
  • Lee, Jae-Hyun (Laboratory of Experimental Pathology, Korea Cancer Center Hospital) ;
  • Kim, Chang-Han (Animal Resource Research Center, Konkuk University)
  • Published : 2000.06.01
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Abstract

We investigated that the extract of Aloe vera L. and its fractions exert antimutagenic activity against Salmonella typhimurium TA98 and TA100, and antileukemic effect against K562 human leukemia cell line. The aqueous ethanolic extract of A. vera L. was revealed to have antimutagenic effect on the AF-2 (2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide) in Salmonella mutation assay. Among the three fractions (fractions A, B and C) separated by silica gel chromatography, fraction C $(50\;{\mu}g/plate)$ exhibited the greatest antimutagenic effect on the AF-2 with inhibition rate of 84 and 90% in Salmonella typhimurium TA98 and TA100, respectively. The fraction C $(500\;{\mu}g/ml)$ inhibited the growth of K562 human leukemia cell line by 93% in MTT assay. However, the components of A. vera L. did not exhibit cytotoxic effect against MDBK bovine normal kidney in MTT assay.

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