The Journal of Korea CHUNA Manual Medicine (대한추나의학회지)

Korean Society of Chuna manual Medicine for Spine and Nerves (척추신경추나의학회)
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A preliminary study for the cerbral infarcted brain atrophy and osteoprosis via female reproductive physiology (Osteoporosis formation and alteration of female sex hormone after Cerebral Infarction)

여성의 뇌졸중후 골다공증에 대한 조경론적(調經論的) 기초연구

  • Lee, Jong-Soo (Dept. of oriental rehabilitation medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Yoon, Sang-Hyub (East-Westmedical research institute, Kyung Hee University)
  • 이종수 (경희대학교 한의과대학 한방재활의학교실) ;
  • 윤상협 (경희대학교 동서의학연구소)
  • Published : 2000.12.20
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Abstract

the aim of this study was to investigate whether osteoporosis can be advanced after cerebral infarction Of not and role of female sex hormone. all animals were classified 4 groups; group of ovariectomy (OVXgroup) group of cerebral infarction( INF group), group of combination ovariectomy and cerebral infarction(OVX + INF group), naturally intact group for control data (NOR group ). cerebral infarction was made by Chen,s method with some modification and ovariectomy was performed by Wayforth,s method. experimental data was collected at 15 days, 1 month, 3 months and 6months after starting observation. serum 17 ${{\beta}-estradiol\;(E_2)}$ was determined by radioimmunoassay, for comparision of osteoporosis formation, bone density, serum osteocalcin, Serum total calcium and phosphorus, Serum AST Concentration, Serum ALT Concentration, Creatinine Concentration were also calculated. we have found that cerebral ischemia decreases not only the serum concentration of 17 ${{\beta}-estradiol\;(E_2)}$ and inhibits but also the physiologically compensatory function of the ovariectomized rats and that the decreased estrogen concentration followed by cerebral infarction have not produced osteoporosis, regretfully.

Keywords

References

  1. 골다공증(골조송증) 대한골대사학회
  2. Endocrinology Biphasic effects of estrogen on gonadotropin-releasing hormone-induced luteinizing hormone release in monolayer cultures of rat and monkey pituitary cells Frawley L.S.;Neill J.D.
  3. Biol. Reprod. v.30 Direct inhibitory hormone responsiveness to luteinizing hormone releasing hormone is specific and of rapid onset Moll G.W. Jr.;Rosenfield R.L.
  4. Endocrinology v.120 Gonadal steroids modulate pulsatile luteinizing hormone sectretion by perifused rat anterior pituitaty cells Kamel F.;Balz J.A.;Kubajak C.L.;Schneider V.A.
  5. Cecil textbook of medicine Riggs B.L.;Osteoporosis;Wyngarrden J.B.;Smith L.H.(eds.)
  6. the Spine Rothmann R.H.;Simeone F.A.
  7. Lancet v.352 no.9145 Cardiovascular and cancer morbidity and mortality and sudden cardiac death in postmenopausal women on oestrogen replacement therapy(ERT) Sourander L.;Rajala T.;Erkkola R.;Helenius H.
  8. Neuropsychiatry Clin. Neurosci. v.7 Lack of postmenopusal estrogen replacement therapy and risk of dementia. Motel K.F.;Meyer J.S.
  9. Cecil textbook of medicine Osteoporosis Riggs B.L.;Wyngarrden J.B.;Smith L.H.
  10. Brain Research v.761 $17\beta$-estradiol protects against NMDA-induced exitotoxicity by direct inhibition of NMDA receptors Weaver C.E.;Chung M.P.;Gibbs T.T.;Farb D.H.
  11. Exp Neurol. v.129 Effects of estrogen replacement on the relative levels of choline acetyltransferase, trka, and nerve growth factor messenger mas in the basal forebrain and hippocampal formation of adults rats Gibbs R.B.;Wu D.;Hersh L.B.;Pfaff D.W.
  12. J. Neurosci. v.16 The effects of ovariectomy and estrogen replacement mrna expression in the basal forebrain on the adult female sprague-dawly rat McMillan P.J.;Singer C.A.;Dorse D.M.
  13. J. Neurochem. v.66 Estrogen attenuate and corticosterone exacerbates exicitotoxicity, oxidative injury and amyloid peptide toxicity in hippocampal neurons Goodman Y.;Bruce A.J.;Cheng B.;Mattson M.P.
  14. Stroke v.31 no.1 Ovariectomy exacerbates and estrogen replacement attenuates photothrombic focal ischemic brain injury in rats Fukuda K.;Yao H.;Ibayashi S.;Nakahara T.;Uchimura H.;Fujishima M.;Hall ED.
  15. Stroke v.30 no.3 Estrogen Provides Neuroprotection in Forebrain Ischemia Through Perfusion-Independent Mechanism in Rats Wang Q;Santizo R;Baughman VL;Pelligrino DA
  16. 胎産心法 閻純새
  17. Stroke v.30 no.8 17 beta-estradiol reduces stroke injury in estrogen-deficient female animals Rusa R.;Alkayed N.J.;Crain B.J.;Traystman R.J.;Kimes A.S.;London E.D.;Edythe D.;Klaus J.A.;Hum P.D.
  18. 精校黃帝內經素問 洪元植
  19. 대한한방부인과학회지 v.8 no.1 左歸飮과 右歸飮이 卵巢摘出 白鼠의 性호르몬과 脂質 및 骨代謝에 미치는 影響 박종철;배종국;강효신
  20. 경희대학교 논문집 v.14 升金丹이 卵巢機能에 미치는 影響 강명자;송병기
  21. 한방재활의학과학회지 v.5 no.1 鹿茸 및 六味地黃湯加鹿茸이 白鼠의 運動 抑制性 骨多孔症에 미치는 影響 김근모
  22. 한방재활의학과학회지 v.5 no.1 龍骨, 牡蠣, 龜板, 鱉甲, 阿膠가 골다공증에 미치는 영향에 관한 문헌적 고찰 김도연;정석희;김성수;이종수;신현대
  23. 임상병리파일 이귀녕;이종순
  24. Experimental and surgical technique in the rat Waynforth H.B.
  25. Participation of cathepsin L on bone resorption v.321 no.2;3 Hisao K.;Takeshi N.;Kahori T.;Hiroshi K.;Koji S.;Terushige K.;Marinka, Drobnic-Kosorok;Brigita L.;Nobuhiko K.
  26. Biochem. J. v.279 Collagenolytic cysteine proteinases of bone tissue;cathepsin B, (pro)cathepsin L and a cthepsin L-like 70 kDa proteinase Jean-Marie D.;Pascale L.;Gilbert V.
  27. DN&P v.8 no.7 Interleukin-6 Receptor Antagonists Brakenhoff P.J.
  28. Clinical Chemistry v.35 Ratioimmunoassay of osteocalcin with polyclonal and monoclonal antibodies Power M.J.;Gosling J.P.;Fottrell P.F.
  29. 臨床檢査法提要 金井泉;金井正光(著);高文社 編纂部(譯)
  30. Calcified Tissue International v.39 Osteoporosis following calcium deficiency in rats Salomon C.D.
  31. Experimental and Clinical Endocrinology v.99 no.2 Serum parathyroid hormone and calcitonin levels following ovariectomy in the adult rat Devlin H.;Lumb G.;Ferguson M.W.
  32. Journal of Reconstuctive Microsurgery v.8 no.1 The effect of calcitonin on osteoporosis of the rat hindlimb induced by denervation and isograft transplantation Shimizu T.;Ishoguro, N.;Miura T.
  33. J. Nut. v.102 Osteoporosis in aging rats incluced by high phosphorus diet Draper H.H.;Sie T.N.;Bergan J.G.
  34. Clin. Chem. v.12 Simplified method for estimation of inorganic phosphorus in body fluid Goldberg H.;Fernandez A.
  35. Bone and Nineral. v.14 Skeletal response of ovariectomized rats to low and high doses of $17\beta$-estrogen Kalu D.N.;Liu C.C.;Salimo E.;Hollis B.;Echon R.;Ray M.
  36. 노인의학개론 조주연
  37. 靈樞經校釋 河北醫學院(校譯)
  38. JAMA v.171 Contemporary therapy of the menopausal syndrome Kupperman H.S.;Watcher B.B.;Blatt M.H.
  39. 부인과학 대한산부인과학회 교과서편찬위원회
  40. 최신 갱년기관리 아주대학교의료원 갱년기연구회
  41. Stroke v.29 no.1 Ischemic Stroke and Use of Estrogen and Estrogen/Pr o-gestrogen as Hormone Replacement Therapy Diana BS;Charles PA
  42. N. Engl. J. Med. v.35 Postmenopausal estrogen and progestin use and the risk of cardiovascular disease Grodstein F;Stampfer MJ;Manson JE(et al.)
  43. 혈류속도 변화측정을 통한 뇌졸중 발병률 연구 Andreas Kastrup
  44. Stroke v.29 no.1 Gender-Linked Brain Injury in Experimental Stroke Alkayed N.J.;Harukuni, I.;Kimes A.S.;London E.D.;Traystman R.J.;Hurn P.D.
  45. Stroke v.31 no.1 Ovariectomy exacerbates and estrogen replacement attenuates photothrombic focal ischemic brain injury in rats Fukuda K.;Yao H.;Ibayashi S.;Nakahara T.;Uchimura H.;Fujishima M.;Hall ED
  46. 대한골대사학회지 v.4 no.2 정상 월경주기에서 골대사 지표의 변화에 대한 연구 김지영;최두석;노정래;김종원;이제호;윤병구
  47. Stroke v.29 no.1 Ischemic Stroke and Use of Estrogen and Estrogen/Progestrogen as Hormone Replacement Therapy Diana B.S.;Charles P.A.
  48. N. Engl. J. Med. v.35 Postmenopausal estrogen and progestin use and the risk of cardiovascular disease Grodstein F;Stampfer MJ;Manson JE(et al.)
  49. Estrogen이 사람조골세포유사세포와 내피세포에서 IL-6, $TGF-\beta$, Nitric Oxide 및 Endothelin-1의 발현 및 분비에 미치는 영향 김관식
  50. 제44차 대한내과학회 추계학술대회 골다공증의 약물치료 김영석
  51. Stroke v.16 Mulicenter trial of hemodilution in ischemic stroke-back-ground and study protocol Scandinavian Stroke Study Group
  52. Am J Phys Med Rehabil v.72 Changes in bone mineral content and density after stroke Hamdy RC;Krishnaswamy G;Cancellaro V;Whalen K;Harvill L
  53. Acta Neurol Scand v.79 The effect of hemiplegia on bone mass and soft tissue complication Iversen E;Hassager C;Christiansen C