The Korean Journal of Physiology and Pharmacology
- 제4권6호
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- Pages.515-523
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- 2000
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Myocardial Protection by Recombinant Soluble P-selectin Glyco-protein Ligand-1: Suppression of Neutrophil and Platelet Interaction Following Ischemia and Reperfusion
- Ham, Sang-Soo (Deparment of Pharmacology, College of Medicine, Chung-Ang University) ;
- Jang, Yoon-Young (Deparment of Pharmacology, College of Medicine, Chung-Ang University) ;
- Song, Jin-Ho (Deparment of Pharmacology, College of Medicine, Chung-Ang University) ;
- Lee, Hyang-Mi (Deparment of Pharmacology, College of Medicine, Chung-Ang University) ;
- Kim, Kwang-Joon (Deparment of Pharmacology, College of Medicine, Chung-Ang University) ;
- Hong, Jun-Sik (Deparment of Pharmacology, College of Medicine, Chung-Ang University) ;
- Shin, Yong-Kyoo (Deparment of Pharmacology, College of Medicine, Chung-Ang University)
- 발행 : 2000.12.21
초록
Polymorphonuclear leukocytes (PMNs) play an important role in myocardial ischemia/reperfusion (MI/R) injury. Moreover, platelets are also important blood cells that can aggravate myocardial ischemic injury. This study was designed to test the effects of PMNs and platelets separately and together in provoking cardiac dysfunction in isolated perfused rat hearts following ischemia and reperfusion. Additional control rat hearts were perfused with