The Korean Journal of Physiology and Pharmacology
- Volume 4 Issue 5
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- Pages.369-378
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- 2000
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Nitroxergic Nerve Relaxes Rat Gastric Smooth Muscle by NO-cGMP Pathway
- Yoon, Yoong-Sam (Department of Pharmacology, College of Medicine, Yeungnam University) ;
- Choi, Hyoung-Chul (Department of Pharmacology, College of Medicine, Yeungnam University) ;
- Jung, Young-Sook (Department of Pharmacology, College of Medicine, Yeungnam University) ;
- Kim, Jong-Ho (Department of Pharmacology, College of Medicine, Yeungnam University) ;
- Lee, Kwang-Youn (Department of Pharmacology, College of Medicine, Yeungnam University) ;
- Sohn, Uy-Dong (Department of Pharmacology, College of Pharmacy, Chungang University) ;
- Ha, Jeoung-Hee (Department of Pharmacology, College of Medicine, Yeungnam University) ;
- Kim, Won-Joon (Department of Pharmacology, College of Medicine, Yeungnam University)
- Published : 2000.10.21
Abstract
This study was undertaken to investigate an involvement of nitroxergic innervation in gastric smooth muscle of rat. Isometric tension study, the measurement of single cell length, NADPH diaphorase stain of smooth muscle layers and neuronal nitric oxide synthase (nNOS) western blotting were performed. Sodium nitroprusside (SNP), a nitric oxide donor, relaxed the muscle strips precontracted by acetylcholine (ACh) in a concentration-dependent manner. Pretreatment of L-arginine decreased the contraction induced by electric field stimulation (EFS). Pretreatment of