The Korean Journal of Physiology and Pharmacology
- Volume 4 Issue 3
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- Pages.263-270
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- 2000
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Impaired Endothelium-Dependent Relaxation is Mediated by Reduced Production of Nitric Oxide in the Streptozotocin-Induced Diabetic Rats
- Park, Kyoung-Sook (Department of Physiology, College of Medicine, Chungnam National University) ;
- Kim, Cuk-Seong (Department of Physiology, College of Medicine, Chungnam National University) ;
- Kang, Sang-Won (Department of Physiology, College of Medicine, Chungnam National University) ;
- Park, Jin-Bong (Department of Physiology, College of Medicine, Chungnam National University) ;
- Kim, Kwang-Jin (Department of Physiology, College of Medicine, Chungnam National University) ;
- Chang, Seok-Jong (Department of Physiology, College of Medicine, Seonam University) ;
- Jeon, Byeong-Hwa (Department of Physiology, College of Medicine, Chungnam National University)
- Published : 2000.06.21
Abstract
To evaluate the involvement of nitric oxide production on the endothelium-dependent relaxation in diabetes, we have measured vascular and endothelial function and nitric oxide concentration, and the expression level of endothelial nitric oxide synthase in the streptozotocin-induced diabetic rats. Diabetic rats were induced by the injection of streptozotocin (50 mg/kg i.v.) in the Sprague-Dawley rats. Vasoconstrictor responses to norepinephrine (NE) showed that maximal contraction to norepinephrine
Keywords
- Streptozotocin-induced diabetic rats;
- Endothelium-dependent relaxation;
- Nitric oxide;
- Endothelial nitric oxide synthase