The Korean Journal of Physiology and Pharmacology
- 제4권3호
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- Pages.243-251
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- 2000
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Effect of Lidocaine-HCl on Microviscosity of Phosphatidylcholine Model Membrane
- Chung, In-Kyo (Departments of Oral and Maxillofacial Surgery and Clinical Pharmacology College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University) ;
- Kim, Inn-Se (Departments of Anesthesiology, College of Medicine and Research Institute for Oral Biotechnology, Pusan National University) ;
- Choi, Chang-Hwa (Departments of Neurosurgery, College of Medicine and Research Institute for Oral Biotechnology, Pusan National University) ;
- Cho, Goon-Jae (Departments of Internal Medicine, College of Medicine and Research Institute for Oral Biotechnology, Pusan National University) ;
- Kim, Jin-Bom (Departments of Preventive and Community Dentistry, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University) ;
- Son, Woo-Sung (Departments of Orthodontics, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University) ;
- Jang, Hye-Ock (Department of Oriental Pathology and Prescription, College of Oriental Medicine, Dong-Eui University) ;
- Yun, Il (Departments of Dental Pharmacology and Biophysics, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University)
- 발행 : 2000.06.21
초록
In order to provide a basis for studying the molecular mechanism of pharmacological action of local anesthetics and to develop a fluorescence spectroscopic method which can detect the microviscosity of native and model membranes using intramolecular excimerization of 1,3-di(l-pyrenyl)propane (Py-3-Py), we examined the effect of lidocaine HCl on the microviscosity of model membranes of phosphatidylcholine fraction extracted from synaptosomal plasma membrane vesicles (SPMVPC). The excimer to monomer fluorescence intensity ratio (I'/I) of Py-3-Py in liquid paraffin was a simple linear function of