The Korean Journal of Physiology and Pharmacology
- Volume 4 Issue 3
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- Pages.235-241
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- 2000
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Expression of Natriuretic Peptide mRNAs in Isoproterenol-Induced Cardiac Hypertrophy in Rats
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Kim, Soo-Kyung
(Department of Pharmacology and Cardiovascular Research Institute, Keimyung University) ;
- Kwon, Gee-Youn (Department of Pharmacology and Cardiovascular Research Institute, Keimyung University) ;
- Chang, Eun-Sook (Department of Pathology, School of Medicine, Keimyung University)
- Published : 2000.06.21
Abstract
We examined the expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) mRNAs upon isoproterenol (Iso)-induced cardiac hypertrophy in rats. Then, we tried to investigate the effects of sympatholytics to see if they can modulate the expression of ANP and BNP. In this study, RT-PCR technique was used to characterize the expression of ANP and BNP in right atrium (RA) and left ventricle (LV) of the hypertrophied rat heart. Histologic findings indicated that stimulation of