The Korean Journal of Physiology and Pharmacology
- 제4권3호
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- Pages.177-183
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- 2000
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Comparison of Neurotoxicity Induced by Some Glutathione Depletors in Mouse Cortical Cell Cultures
- Lee, Gee-Woon (Departments of Anatomy, Chonnam National University Medical School, Chonnam National University Research Institute of Medical Sciences) ;
- Lee, Kuy-Sook (Departments of Pharmacology, Chonnam National University Medical School, Chonnam National University Research Institute of Medical Sciences) ;
- Park, Sah-Hoon (Departments of Physiology, Chonnam National University Medical School, Chonnam National University Research Institute of Medical Sciences) ;
- Bae, Choon-Sang (Departments of Anatomy, Chonnam National University Medical School, Chonnam National University Research Institute of Medical Sciences) ;
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Kim, Jong-Keun
(Departments of Pharmacology, Chonnam National University Medical School, Chonnam National University Research Institute of Medical Sciences)
- 발행 : 2000.06.21
초록
We examined the neurotoxic effects of 3 glutathione (GSH) depletors, buthionine sulfoximine (BSO), diethyl maleate (DEM) and phorone, under the presence of trolox, cycloheximide (CHX), pyrrolidine dithiocarbamate (PDTC) or MK-801 in primary mouse cortical cell cultures. All three depletors induced neuronal death in dose and exposure time dependent manner, and decreased total cellular GSH contents. The patterns of the neuronal death and the GSH decrements were dependent on the individual agents. DEM
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