The Korean Journal of Physiology and Pharmacology
- 제4권2호
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- Pages.159-167
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- 2000
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Selective Cytotoxicity of a Novel Platinum(II) Coordination Complex on Human Bladder Cancer Cell Lines and Normal Kidney Cells
- Jung, Jee-Chang (Departments of Pharmacology, College of Pharmacy, Kyung Hee University) ;
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Chung, Joo-Ho
(Departments of Pharmacology, College of Pharmacy, Kyung Hee University) ;
- Chang, Sung-Goo (Departments of Urology, School of Medicine, College of Pharmacy, Kyung Hee University) ;
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Rho, Young-Soo
(Department of Pharmacochemistry, College of Pharmacy, Kyung Hee University)
- 발행 : 2000.04.21
초록
We have synthesized a novel platinum(II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-dichloroethane (DCE) as a leaving group. In addition, nitrate was added to improve the water-solubility. A new series of [Pt(cis-DACH)(DCE)]