약학회지 (YAKHAK HOEJI)
- 제44권6호
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- Pages.595-600
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- 2000
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
사람 카다베르 피부를 통한 케토롤락 트로메타민의 경피 흡수에 L-menthol이 미치는 영향
Effect of L-Menthol on the Percutaneous Absorption of Ketorolac Tromethamine Across Human Cadaver Skin
- 이용석 (중앙대학교 약학대학 약품물리화학교실) ;
- 오흥설 (중앙대학교 약학대학 약품물리화학교실) ;
- 김하형 (중앙대학교 약학대학 약품물리화학교실) ;
- 이광표 (중앙대학교 약학대학 약품물리화학교실)
- Lee, Yong-Seok (Division of Physical Pharmacy, College of Pharmacy, Chung-Ang University) ;
- Oh, Heung-Seol (Division of Physical Pharmacy, College of Pharmacy, Chung-Ang University) ;
- Kim, Ha-Hyung (Division of Physical Pharmacy, College of Pharmacy, Chung-Ang University) ;
- Lee, Kwang-Pyo (Division of Physical Pharmacy, College of Pharmacy, Chung-Ang University)
- 발행 : 2000.12.30
초록
Transdermal delivery of ketorolac tromethamine, a potent non-narcotic analgesic, through human cadaver skin was investigated in vitro. A mixture of ethanol/water (40/60) containing 0, 1, 3, 5, and 8 (w/v)% L-menthol were used as a vehicle and penetration enhancer respectively. The permeation of ketorolac through human cadaver skin from saturated drug solution was evaluated at