약학회지 (YAKHAK HOEJI)
- 제44권6호
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- Pages.552-557
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- 2000
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
육미지황탕이 카드뮴 중독된 흰쥐의 간장 약물대사 기능에 미치는 영향
Effects of Yukmijihwang-Tang on the Hepatic Microsomal Function of Cd-poisoned Rat
- Suh, Eun-Sil (College of Pharmacy, Woosuk University) ;
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Lim, Jong-Pil
(College of Pharmacy, Woosuk University)
- 발행 : 2000.12.30
초록
In order to investigate the effects of Yukmijihwang-Tang on the hepatic microsomal function of Cd-poisoned rats, 3 mg/kg of cadmium (Cd) and 500 mg/kg of Yukmijihwang-Tang extract (YJT), a herbal hepatoprotective medicine, were administered concurrently to rats for 4 weeks. The levels of protein, aniline hydroxylase (AH) and malondialdehyde (MDA) were increased in Cd-treated group. This increase was suppressed by treatment or YJT. The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), glucose-6-phosphatase (G-6-P) and