약학회지 (YAKHAK HOEJI)
- 제44권6호
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- Pages.528-533
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- 2000
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
난용성 항진균제 이트라코나졸의 액상제제화에 의한 생체이용율 개선
Enhanced Bioavailability of Itraconazole in Liquid Preparation
- Hwang, Woo-Sin (R & D Center, KOLON Pharmaceutical Inc.) ;
- Kwon, Kwang-Il (College of Pharmacy, Chungnam National University) ;
- Bang, Kyu-Ho (R & D Center, KOLON Pharmaceutical Inc.)
- 발행 : 2000.12.30
초록
This study was to develop an effective itraconazole liquid preparation which exhibits an enhanced bioavailability. The solubility of itraconazole was increased (72-fold) in itraconazole liquid preparation as compared with itraconazole powder. The dissolution rate of itraconazole was higher for itraconazole liquid preparation filled into a hard gelatin capsule with 90% release within 20 min as compared to 55% for