약학회지 (YAKHAK HOEJI)
- 제44권6호
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- Pages.511-520
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- 2000
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
용매증발법에 의한 부피바카인 microsphere의 제조 및 평가
Preparation and Evaluation of Bupivacaine Microspheres by a Solvent Evaporation Method
- Kwak, Son-Hyok (College of Pharmacy, Chungnam National University) ;
- Hwang, Sung-Joo (College of Pharmacy, Chungnam National University) ;
- Lee, Byung-Chul (Department of Chemical Engineering, Hannam University)
- 발행 : 2000.12.30
초록
Various bupivacaine-loaded microspheres were prepared from poly (d,l-lactide) (PLA) or poly (d,l-lactic-co-glycolide) (PLGA) by a solvent evaporation method for the sustained release of drug. PLA and PLGA microspheres were prepared by w/o/w and w/o/o multiple emulsion solvent evaporation, respectively. The effects of process conditions such as emulsification speed, emulsifier type, emulsifier concentration and internal/external phase ratio on the characteristics of microspheres were investigated. The prepared microspheres were characterized for their drug loading, size distribution, surface morphology and release kinetics. Drug loading efficiency was higher in the microspheres prepared by w/o/o multiple emulsion than that by w/o/w multiple emulsion method, because the solubility of bupivacaine HCI was decreased in oil phase compared with water phase. The prepared microspheres had an average diameter between 1 and
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