적정약물요법을 위한 TDM의 임상적 응용

Clinical Applications of Therapeutic Drug Monitoring for the Optimal Drug Therapy

  • 윤영란 (인제대학교 의과대학 약리학교실 및 부산 백병원 임상약리센터) ;
  • 임영채 (전남대학교 의과대학 약리학교실 및 의과학연구소)
  • Yoon, Young-Ran (Departmet of Pharmacology, College of Medicine, Inje University and Clinical Pharmacology Center, IJUPH) ;
  • Lim, Young-Chai (Department of Pharmacology, Medical School and Institute of Medical Sciences, Chonnam National University)
  • 발행 : 2000.06.30

초록

Therapeutic drug monitoring (TDM) among various fields of clinical pharmacology plays the vital role in order to achieve the indivisualization of optimal drug therapy, which is the process of maximizing therapeutic effects and minimizing side effecs, simultaneously. Variable drug responses are largely due to the individual pharmacokinetic variations. Therefore in TDM it is very important to keep optimal drug concentrations, which makes it possible to optimize the clinical outcomes of each patient. In recent, the introduction of clinical pharmacokinetic principles and development of assay methods makes TDM more prevalent. This article describes the clinical significance, functions, and applications of TDM in several aspects. TDM indications, concepts and examples of therapeutic range are also described. The features which should be strived for in each step of TDM process (the decision to request a drug level, blood sampling, laboratory measurement, clinical interpretation of drug concentration, and production of individualized dosage regimen and dosage adjustment) are discussed.

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