Journal of Korean Society for Clinical Pharmacology and Therapeutics (임상약리학회지)

Korean Society for Clinical Pharmacology and Therapeutics (대한임상약리학회)
권호 표지

Pharmacokinetic/Pharmacodynamic Principles for Individualized Optimum Pharmacotherapy

적정약물요법을 위한 약동학/약력학적 개념

  • Shon, Ji-Hong (Department of Pharmacology, Inje University College of Medicine and Clinical Pharmacology Center, Pusan Paik Hospital) ;
  • Shin, Jae-Gook (Department of Pharmacology, Inje University College of Medicine and Clinical Pharmacology Center, Pusan Paik Hospital)
  • 손지홍 (인제대학교 의과대학 약리학교실 및 부산백병원 임상약리센터) ;
  • 신재국 (인제대학교 의과대학 약리학교실 및 부산백병원 임상약리센터)
  • Published : 2000.06.30

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Abstract

The dose-response relationships of a drug are quite different among subjects due to pharmacokinetic and/or pharmacodynamic variations. The quantitative estimation of pharmacokinetic and/or pharmacodynamic characteristics of an individual subject is required for designing the optimum individualized dosage regimen for the subject. Concentration controlled pharmacotherapy can be one approach to minimize the inappropriate dosing caused by the pharmacokinetic variation. This article introduces some basic pharmacokinetic/pharmacodynamic concepts to understand the dose-response relationship of a given drug and to design optimum pharmacotherapy in a given patient with the data derived from therapeutic drug monitoring and/or literatures.

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