Journal of Korean Society for Clinical Pharmacology and Therapeutics (임상약리학회지)

Korean Society for Clinical Pharmacology and Therapeutics (대한임상약리학회)
권호 표지

Lamivudine and Interferon Alpha Combination Treatment in Patients with Chronic Hepatitis B

B형 만성 간염 환자에서 인터페론 단독 요법과 인터페론과 라미부딘 병합 요법의 비교

  • Jeong, Eun-Mi (Department of Internal Medicine, Central Laboratory of Internal Medicine, Pochon CHA University College of Medicine) ;
  • Hong, Chang-Kwon (Department of Internal Medicine, Central Laboratory of Internal Medicine, Pochon CHA University College of Medicine) ;
  • Oh, Seong-Wook (Department of Internal Medicine, Central Laboratory of Internal Medicine, Pochon CHA University College of Medicine) ;
  • Park, Jae-Wan (Department of Internal Medicine, Central Laboratory of Internal Medicine, Pochon CHA University College of Medicine) ;
  • Lee, June-Sung (Department of Internal Medicine, Central Laboratory of Internal Medicine, Pochon CHA University College of Medicine) ;
  • Kim, Kyung-Chul (Department of Internal Medicine, Central Laboratory of Internal Medicine, Pochon CHA University College of Medicine) ;
  • Kim, Bai-Young (Department of Internal Medicine, Central Laboratory of Internal Medicine, Pochon CHA University College of Medicine) ;
  • Hong, Sung-Pyo (Department of Internal Medicine, Central Laboratory of Internal Medicine, Pochon CHA University College of Medicine) ;
  • Park, Pil-Won (Department of Internal Medicine, Central Laboratory of Internal Medicine, Pochon CHA University College of Medicine) ;
  • Rim, Kyu-Sung (Department of Internal Medicine, Central Laboratory of Internal Medicine, Pochon CHA University College of Medicine) ;
  • Kim, Se-Hyun (Department of Preventive Medicine, Pochon CHA University Colleg of Medicine) ;
  • Hwang, Seong-Gyu (Department of Internal Medicine, Central Laboratory of Internal Medicine, Pochon CHA University College of Medicine)
  • 정은미 (포천중문의과대학 내과학교실, 내과중앙연구소) ;
  • 홍창권 (포천중문의과대학 내과학교실, 내과중앙연구소) ;
  • 오성욱 (포천중문의과대학 내과학교실, 내과중앙연구소) ;
  • 박재완 (포천중문의과대학 내과학교실, 내과중앙연구소) ;
  • 이준성 (포천중문의과대학 내과학교실, 내과중앙연구소) ;
  • 김경철 (포천중문의과대학 내과학교실, 내과중앙연구소) ;
  • 김배영 (포천중문의과대학 내과학교실, 내과중앙연구소) ;
  • 홍성표 (포천중문의과대학 내과학교실, 내과중앙연구소) ;
  • 박필원 (포천중문의과대학 내과학교실, 내과중앙연구소) ;
  • 임규성 (포천중문의과대학 내과학교실, 내과중앙연구소) ;
  • 김세현 (포천중문의과대학 예방의학교실) ;
  • 황성규 (포천중문의과대학 내과학교실, 내과중앙연구소)
  • Published : 2000.06.30

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Abstract

Background/Aims: Hepatitis B virus (HBV) is associated with clinically significant chronic infection that may lead to the development of cirrhosis or even hepatocellular carcinoma. However, interferon alpha is effective in only 25-40% of chronic hepatitis B patients. The purpose of this study was to evaluate the effectiveness of interferon and lamivudine combination treatment comparing with interferon alone. Methods : Twenty patients with chronic hepatitis B(moderate to severe activity) were randomized to with interferon alone (11 patients) or combination (9 patients) therapy for 24 weeks. The patients were monthly evaluated, biochemically and serologically. Results : There was no statistical difference between both groups in HBeAg seroconversion rate and ALT normalizaion rate at the end of treatment. But, HBV DNA suppression rate was significantly higher in combination group (100%) than the interferon alone group (54%). No serious side effects were noted in both groups. Conclusion : Combinaton therapy with alpha interferon plus lamivudine given for 24 weeks appears safe and is well tolerated. But, combination therapy was no more efficient than interferon alone in HBeAg seroconversion except HBV DNA suppression rate during the treatment period.

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