Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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A Case of Convulsive Seizure Development Induced by Clozapine

Clozapine 투여 후 경련성 발작을 보인 환자 1례

  • Seo, Man Kil (Department of Neuropsychiatry, College of Medicine, SungKyunKwan University, Samsung Medical Center) ;
  • Kim, Doh Kwan (Department of Neuropsychiatry, College of Medicine, SungKyunKwan University, Samsung Medical Center) ;
  • Kim, Eyong (Department of Neuropsychiatry, College of Medicine, SungKyunKwan University, Samsung Medical Center)
  • 서만길 (성균관대학교 의과대학 삼성서울병원 신경정신과학교실) ;
  • 김도관 (성균관대학교 의과대학 삼성서울병원 신경정신과학교실) ;
  • 김이영 (성균관대학교 의과대학 삼성서울병원 신경정신과학교실)
  • Published : 1999.06.25
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Abstract

The authors described a case of male schizophrenia who developed myoclonic jerk repeatedly and one episode of convulsive seizure during the treatment of clozapine. According to literatures and reported cases, myoclonic jerks induced in a small amount of clozapine may precede and predict the development of a convulsive seizure. Therefore clinicians have to pay attention to the development of a myoclonic jerk during the administration of clozapine. They may decrease the dosage of clozapine step by step at first in the convulsive state, and observe EEG changes of patients frequently.

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