Korean Journal of Biological Psychiatry (생물정신의학)
- Volume 6 Issue 1
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- Pages.89-95
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- 1999
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
Association of Tardive Dyskinesia with Cognitive Deficit in Schizophrenia
정신분열병에서 지연성 운동장애와 인지결함의 연관성
- Jang, Tae-Seob (Dong Nam Psychiatric Hospital) ;
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Oh, Byoung-Hoon
(Department of Neuropsychiatry, Yonsei University, College of Medicine) ;
- Cheon, Jin-Sook (Department of Neuropsychiatry, Kosin University, School of Medicine)
- Published : 1999.06.25
Abstract
To understand a mechanism of underlying cognitive deficit in schizophrenia, the risk factors, cognitive function, blood dopamine concentrations and glutamate dehydrogenase activities of male schizophrenics with tardive dyskinesia(N=30) were compared with those of schizophrenics without tardive dyskinesia(N=30). The results were as following ; 1) The age, duration of illness and duration of medication were significantly more in schizophrenics with tardive dyskinesia than schizophrenics without tardive dyskinesia(respectively p<0.005, p<0.0001, p<0.0001). 2) The scores of MMSE, TIQ, VIQ and PIQ were significantly lower in schizophrenics with tardive dyskinesia than schizophrenics without tardive dyskinesia (rspectively p<0.0001). 3) Plasma dopamine concentrations were tended to be higher, and serum glutamate dehydrogenase activities were tended to be lower in schiz-ophrenics with tardive dyskinesia than schizophrenics without tardive dyskinesia. 4) The cognitive deficit seemed to be negatively correlated with duration of illness and duration of medication(respectively