Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Association of Tardive Dyskinesia with Cognitive Deficit in Schizophrenia

정신분열병에서 지연성 운동장애와 인지결함의 연관성

  • Jang, Tae-Seob (Dong Nam Psychiatric Hospital) ;
  • Oh, Byoung-Hoon (Department of Neuropsychiatry, Yonsei University, College of Medicine) ;
  • Cheon, Jin-Sook (Department of Neuropsychiatry, Kosin University, School of Medicine)
  • 장태섭 (동남정신병원) ;
  • 오병훈 (연세대학교 의과대학 신경정신과학교실) ;
  • 전진숙 (고신대학교 의과대학 신경정신과학교실)
  • Published : 1999.06.25
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Abstract

To understand a mechanism of underlying cognitive deficit in schizophrenia, the risk factors, cognitive function, blood dopamine concentrations and glutamate dehydrogenase activities of male schizophrenics with tardive dyskinesia(N=30) were compared with those of schizophrenics without tardive dyskinesia(N=30). The results were as following ; 1) The age, duration of illness and duration of medication were significantly more in schizophrenics with tardive dyskinesia than schizophrenics without tardive dyskinesia(respectively p<0.005, p<0.0001, p<0.0001). 2) The scores of MMSE, TIQ, VIQ and PIQ were significantly lower in schizophrenics with tardive dyskinesia than schizophrenics without tardive dyskinesia (rspectively p<0.0001). 3) Plasma dopamine concentrations were tended to be higher, and serum glutamate dehydrogenase activities were tended to be lower in schiz-ophrenics with tardive dyskinesia than schizophrenics without tardive dyskinesia. 4) The cognitive deficit seemed to be negatively correlated with duration of illness and duration of medication(respectively ${\gamma}$=-0.496, ${\gamma}$=-0.615).

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