The Korean Journal of Pain
- 제12권1호
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- Pages.1-7
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- 1999
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- 2005-9159(pISSN)
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- 2093-0569(eISSN)
흰쥐에서 척수강내로 투여한 AMPA 수용체 길항제, ACEA 2085의 항통각과민 효과
The Effect of Intrathecal ACEA 2085, Highly Selective AMPA Receptor Antagonist on the Hyperalgesia Observed after Thermal Injury in the Rat
- 전종헌 (한양대학교 의과대학 마취과학교실) ;
-
염종훈
(한양대학교 의과대학 마취과학교실) ;
- 김용철 (한양대학교 의과대학 마취과학교실) ;
- 심재철 (한양대학교 의과대학 마취과학교실) ;
- 김경헌 (한양대학교 의과대학 마취과학교실) ;
-
서정국
(한양대학교 의과대학 마취과학교실) ;
- 유희구 (한양대학교 의과대학 마취과학교실)
- Jun, Jong-Hun (Department of Anesthesiology, Hanyang University College of Medicine) ;
-
Yeom, Jong-Hoon
(Department of Anesthesiology, Hanyang University College of Medicine) ;
- Kim, Yong-Chul (Department of Anesthesiology, Hanyang University College of Medicine) ;
- Shim, Jae-Chul (Department of Anesthesiology, Hanyang University College of Medicine) ;
- Kim, Kyoung-Hun (Department of Anesthesiology, Hanyang University College of Medicine) ;
-
Suh, Jung-Kook
(Department of Anesthesiology, Hanyang University College of Medicine) ;
- Yoo, Hee-Koo (Department of Anesthesiology, Hanyang University College of Medicine)
- 발행 : 1999.05.31
초록
Background: To study the role of spinal alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors in pain behaviors caused by mild burn, we examined the effect of intrathecal administered ACEA 2085, which has been recently characterized as a high potency competitive AMPA receptor antagonist, on the thermal hyperalgesia state induced by mild burn. Methods: A thermal injury was induced by applying the left hind paw to a thermal surface (