Journal of Ginseng Research
- Volume 23 Issue 4
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- Pages.239-246
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- 1999
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- 1226-8453(pISSN)
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- 2093-4947(eISSN)
Spinal Co-Administration of Ginsenosides with Morphine Prevents the Development of Opioid Tolerance and Attenuates Opioid Dependence
- Choi Seok (Dept. of Physiology. College of Veterinary Medicine. Chonnam National University) ;
- Jung Se-Yeon (Dept. of Physiology. College of Veterinary Medicine. Chonnam National University) ;
- Nah Jin-Ju (Dept. of Physiology. College of Veterinary Medicine. Chonnam National University) ;
- Ahn Eun-Soon (Dept. of Physiology. College of Veterinary Medicine. Chonnam National University) ;
- Kim Yoon-Hee (Dept. of Physiology. College of Veterinary Medicine. Chonnam National University) ;
- Nam Ki-Yeul (KGTRI) ;
- Kim Seok-Chang (KGTRI) ;
- Ko Sung-Ryong (KGTRI) ;
- Rhim Hyewhon (Biomedical Research Center, KIST) ;
- Nah Seung-Yeol (Dept. of Physiology, College of Veterinary Medicine, Chonnam National University)
- Published : 1999.12.01
Abstract
The analgesic effect of ginsenosides or morphine was determined following intrathecal (i.t.) administration in rat tail-flick test. The effects of intrathecal co-administration of ginsenosides with morphine on the development of opioid tolerance and dependence were also examined using rat tail-flick test and naloxone-pre-cipitated withdrawal, respectively. Administration of ginsenosides (i.t.) produced a weak antinociception in a dose-dependent manner. Administration of morphine (i.t.) also produced antinociception in a dose-dependent manner. The
백서를 이용하여 진세노사이드 흑은 모르핀을 척수강내 투여한 다음 tail-flick test를 통하여 진통 작용을 연구하였다. 또한, 진세노사이드를 모르핀과 함께 척수강내 장기 처리할 경우 모르핀에 의한 내성 및 의존성 유발에 미치는 영향을 연구하였다. 연구 결과, 척수강내 진세노사이드의 투여는 200