Journal of Ginseng Research
- Volume 23 Issue 1 Serial No. 53
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- Pages.13-20
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- 1999
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- 1226-8453(pISSN)
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- 2093-4947(eISSN)
Effects of Compositions of Saponin Fraction from Korean Red Ginseng in the Relaxation of Rabbit and Rat Corpus Cavernosum
토끼와 흰쥐 음경해면체 이완작용에 미치는 홍삼사포닌 분획별 효과
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Choi Young Deuk
(Department of Urology, Yonsei University College of Medicine) ;
- Park Jin Ah (Department of Urology, Yonsei University College of Medicine) ;
- Choi Hyung Ki (Department of Urology, Yonsei University College of Medicine) ;
- Nam Ki Yeul (Korea Ginseng & Tabacco Research Institute)
- Published : 1999.03.01
Abstract
We previously reported that Korean red ginseng (KRG) has a relaxation effect on the smooth muscles of corpus cavernosum via nitric oxide (NO) pathway and calcium and potassium channels. However, it is suggested that the active ingredients of KRG might be different depending on the sources of preparation, and there might be differences in actions for different compositions. We first investigated the composition of KRG saponins according to the extractions of the various sources of KRG, then with these extractions the relaxation effects were evaluated in vitro and hemodynamical in vivo using New Zealand white rabbit and rat corpus cavernosum. The total compositions of ginsenoside
사포닌 함량과 PD계 사포닌과 PT계 사포닌의 조성 비율이 상이한 사포닌 분획물 TS-1, TS-2, TS-3 즉 주종 ginsenoside의 총함량