육일순기탕(六一順氣湯) 추출물(抽出物)이 생쥐의 전뇌허혈(全腦虛血)에 미치는 영향(影響)

The Effect of Yukilsunki-tang extracts on Global Cerebral Ischemia in mice

생쥐의 전뇌허혈(全腦虛血) 모델에서 potassium cyanide 유발(誘發) 혼수시간(昏睡時間) 및 생존시간(生存時間), 감압성(減壓性) 무효소(無酵素) 부하시(負荷時) 생존시간(生存時間)을 측정(測定)하여 전뇌처혈시(全腦處血時) 뇌순환대사(腦循環代謝) 개선(改善) 효과(效果)를 관찰(觀察)하였다. KCN 유발(誘發) 혼수시간(昏睡時間)의 단축(短縮), 치사양(致死量)의 KCN에 대한 생존시간(生存時間)의 연장(延長), 감압(減壓)에 의한 무산소(無酸素) 부하시(負荷時) 생존시간(生存時間)의 연장(延長) 효과(效果)가 나타났다.

The effect of Yukilsunki-tang extracts on global cerebral ischemia were investigated in this study. The multiple parameters of global cerebral ischemia assessed in mice included the duration of KCN-induced(1.8mg/kg i.v.) coma, the survival time of KCN-induced(3.0mg/kg i.v.) coma, the survival time exposed to hypoxia induced by vacuum pump. In the case of global cerebral ischemia International Cancer Research mice were used and divided into two groups at random Group A, normal control, was treated after oral administration of normal saline. Group B, experimental control, was treated after oral administration of 13.2mg/20g of Yukilsunki-tang extracts. Each treatment was KCN-induced(1.8mg/kg i.v.) coma, KCN-induced(3.0mg/kg i.v.) coma and exposure to hypoxia induced by vacuum pump. The results were obtained as follows ; In global cerebral ischemia, Yukilsunki-tang extracts significantly prolonged the duration of KCN-induced(1.8mg/kg i.v.) coma, the survival time of KCN-induced(3.0mg/kg i.v.) coma and the survival time of exposure to hypoxia induced by vacuum pump in mice. Conclusion Yukisunki-tang extracts had a significant effect on Global cerebral ischemia.