Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

THE HISTOLOGIC STUDY OF THE RAT TEMPOROMANDIBULAR JOINT CHANGE FOLLOWING OVARIECTOMY

자성백서의 난소절제시 악관절 변화에 관한 조직학적 연구

  • Jung, Hae-Su (Dept. of Oral and Maxillofacial Surgery, Collage of Dentistry, Dankook University) ;
  • Kim, Kyung-Wook (Dept. of Oral and Maxillofacial Surgery, Collage of Dentistry, Dankook University) ;
  • Lee, Jae-Hoon (Dept. of Oral and Maxillofacial Surgery, Collage of Dentistry, Dankook University) ;
  • Kim, Chang-Jin (Dept. of Pathology, Collage of Medicine, Soonchunhyang University)
  • 정회수 (단국대학교 치과대학 구강악안면외과학교실) ;
  • 김경욱 (단국대학교 치과대학 구강악안면외과학교실) ;
  • 이재훈 (단국대학교 치과대학 구강악안면외과학교실) ;
  • 김창진 (순천향대학교 의과대학 병리학교실)
  • Received : 1999.01.05
  • Accepted : 1999.02.05
  • Published : 1999.06.30
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Abstract

This investigation studied the effect of ovariectomy on the temporomandibular joint (TMJ) of rat. Forty female Sprauge-Dawley strain white rats, each weighing about 200grams were used and divided into two groups. The one group was performed ovariectomy, and the other was performed sham operation. Both group were killed at the intervals of 3 days, 1, 2, 4, and 8 weeks postoperatively, paraffin section were stained with H&E, MT and histomorphometric study of the TMJ was performed in a synchronous manner with an sham operated control group The result were as follows: 1. At 4 weeks after ovariectomy, an adhesion between the inferior surface of the articular disc and the condyle was observed in the central portion. At 8 weeks after ovariectomy, a focal thickening of the bone (osteophyte) was observed in anterior portion and there was a marked decrease in the trabecular bone in the posterior region. 2. The thickness of cartilage zone was increased at 2 weeks postopratively in the central portion, and decreased at 4 weeks postopratively in the posterior portion. The thickness of transitional zone was decreased at 1 week postoperatively in the anterior and proliferating zone was decreased postoperatively. The thickness of articular zone was decreased at 3 days postopratively in the anterior portion, and decreased at 1 week postoperatively in the central portion. From the above finding, we could conclue that estrogen deficiency in rats causes alteration of TMJ in marked early stage.

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